FN Archimer Export Format
PT J
TI Ancestral gene acquisition as the key to virulence potential in environmental Vibrio populations
BT 
AF BRUTO, Maxime
   LABREUCHE, Yannick
   JAMES, Adele
   PIEL, Damien
   CHENIVESSE, Sabine
   PETTON, Bruno
   POLZ, Martin F.
   LE ROUX, Frederique
AS 1:1,2;2:1,2;3:1,2;4:1,2;5:2;6:1,3;7:4;8:1,2;
FF 1:PDG-RBE-PFOM;2:PDG-RBE-PFOM;3:PDG-RBE-PFOM;4:PDG-RBE-PFOM;5:;6:PDG-RBE-PFOM-LPI;7:;8:PDG-RBE-PFOM;
C1 IFREMER, Unite Physiol Fonct Organismes Marins, CS 10070, F-29280 Plouzane, France.
   UPMC Paris 06, Sorbonne Univ, Integrat Biol Marine Models, Stn Biol Roscoff,CNRS,UMR 8227,CS 90074, F-29688 Roscoff, France.
   IFREMER, LEMAR, UMR 6539, 11 Presquile Vivier, F-29840 Argenton En Landunvez, France.
   MIT, Parsons Lab Environm Sci & Engn, Cambridge, MA 02139 USA.
C2 IFREMER, FRANCE
   UNIV PARIS 06, FRANCE
   IFREMER, FRANCE
   MIT, USA
SI ROSCOFF
   BREST
   ARGENTON
SE PDG-RBE-PFOM
   PDG-RBE-PFOM-LPI
UM LEMAR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 9.493
TC 23
UR https://archimer.ifremer.fr/doc/00452/56370/57967.pdf
   https://archimer.ifremer.fr/doc/00452/56370/57968.pdf
LA English
DT Article
AB Diseases of marine animals caused by bacteria of the genus Vibrio are on the rise worldwide. Understanding the eco-evolutionary dynamics of these infectious agents is important for predicting and managing these diseases. Yet, compared to Vibrio infecting humans, knowledge of their role as animal pathogens is scarce. Here we ask how widespread is virulence among ecologically differentiated Vibrio populations, and what is the nature and frequency of virulence genes within these populations? We use a combination of population genomics and molecular genetics to assay hundreds of Vibrio strains for their virulence in the oyster Crassostrea gigas, a unique animal model that allows high-throughput infection assays. We show that within the diverse Splendidus clade, virulence represents an ancestral trait but has been lost from several populations. Two loci are necessary for virulence, the first being widely distributed across the Splendidus clade and consisting of an exported conserved protein (R5.7). The second is a MARTX toxin cluster, which only occurs within V. splendidus and is for the first time associated with virulence in marine invertebrates. Varying frequencies of both loci among populations indicate different selective pressures and alternative ecological roles, based on which we suggest strategies for epidemiological surveys. 
PY 2018
PD DEC
SO Isme Journal
SN 1751-7362
PU Nature Publishing Group
VL 12
IS 12
UT 000450781600012
BP 2954
EP 2966
DI 10.1038/s41396-018-0245-3
ID 56370
ER

EF