FN Archimer Export Format
PT J
TI Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird
BT 
AF SOULSBURY, Carl D.
   LIPPONEN, Anssi
   WOOD, Kristie
   MEIN, Charles A.
   HOFFMAN, Joseph I.
   LEBIGRE, Christophe
AS 1:1;2:2,3;3:4;4:4;5:5;6:6;
FF 1:;2:;3:;4:;5:;6:;
C1 Univ Lincoln, Sch Life Sci, Lincoln, England.
   Univ Jyvaskyla, Dept Biol & Environm Sci, Jyvaskyla, Finland.
   Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland.
   Queen Mary Univ London, Barts & London Sch Med & Dent, Genome Ctr, London, England.
   Univ Bielefeld, Dept Anim Behav, Bielefeld, Germany.
   French Res Inst Exploitat Sea, Plouzane, France.
C2 UNIV LINCOLN, UK
   UNIV JYVASKYLA, FINLAND
   UNIV EASTERN FINLAND, FINLAND
   UNIV LONDON, UK
   UNIV BIELEFELD, GERMANY
   French Res Inst Exploitat Sea, Plouzane, France.
IN DOAJ
IF 2.415
TC 5
UR https://archimer.ifremer.fr/doc/00452/56391/58029.pdf
   https://archimer.ifremer.fr/doc/00452/56391/58030.pdf
LA English
DT Article
DE ;AgRP;coloration;epigenetics;heterozygosity;melanin;sexual ornament
AB Secondary sexual trait expression can be influenced by fixed individual factors (such as genetic quality) as well as by dynamic factors (such as age and environmentally induced gene expression) that may be associated with variation in condition or quality. In particular, melanin-based traits are known to relate to condition and there is a well-characterized genetic pathway underpinning their expression. However, the mechanisms linking variable trait expression to genetic quality remain unclear. One plausible mechanism is that genetic quality could influence trait expression via differential methylation and differential gene expression. We therefore conducted a pilot study examining DNA methylation at a candidate gene (agouti-related neuropeptide: AgRP) in the black grouse Lyrurus tetrix. We specifically tested whether CpG methylation covaries with age and multilocus heterozygosity (a proxy of genetic quality) and from there whether the expression of a melanin-based ornament (ultraviolet-blue chroma) correlates with DNA methylation. Consistent with expectations, we found clear evidence for age- and heterozygosity-specific patterns of DNA methylation, with two CpG sites showing the greatest DNA methylation in highly heterozygous males at their peak age of reproduction. Furthermore, DNA methylation at three CpG sites was significantly positively correlated with ultraviolet-blue chroma. Ours is the first study to our knowledge to document age- and quality-dependent variation in DNA methylation and to show that dynamic sexual trait expression across the lifespan of an organism is associated with patterns of DNA methylation. Although we cannot demonstrate causality, our work provides empirical support for a mechanism that could potentially link key individual factors to variation in sexual trait expression in a wild vertebrate. 
PY 2018
PD JUN
SO Ecology And Evolution
SN 2045-7758
PU Wiley
VL 8
IS 13
UT 000439769400015
BP 6547
EP 6557
DI 10.1002/ece3.4132
ID 56391
ER

EF