Transgenerational plasticity and antiviral immunity in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus 1 (OsHV-1)

Type Article
Date 2019-02
Language English
Author(s) Lafont Maxime1, 2, 5, Goncalves Priscila1, 3, Guo Ximing4, Montagnani CarolineORCID2, Raftos David1, 3, Green Timothy1, 3
Affiliation(s) 1 : Sydney Inst Marine Sci, Sydney, NSW, Australia.
2 : Univ Perpignan, IFREMER, CNRS, IHPE,Univ Montpellier, Via Domitia, Perpignan, France.
3 : Macquarie Univ, Dept Biol Sci, Sydney, NSW, Australia.
4 : Rutgers State Univ, Haskin Shellfish Res Lab, Port Norris, NJ USA.
5 : Univ Perpignan, IFREMER, CNRS, IHPE,Univ Montpellier, Via Domitia, Perpignan, France.
Source Developmental And Comparative Immunology (0145-305X) (Elsevier Sci Ltd), 2019-02 , Vol. 91 , P. 17-25
DOI 10.1016/j.dci.2018.09.022
WOS© Times Cited 16
Keyword(s) Crassostrea gigas, OsHV-1, Transgenerational immune priming, Trained immunity, RNA-seq
Abstract

The oyster's immune system is capable of adapting upon exposure to a pathogen-associated molecular pattern (PAMP) to have an enhanced secondary response against the same type of pathogen. This has been demonstrated using poly(I:C) to elicit an antiviral response in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus (OsHV-1). Improved survival following exposure to poly(I:C) has been found in later life stages (within-generational immune priming) and in the next generation (transgenerational immune priming). The mechanism that the oyster uses to transfer immunity to the next generation is unknown. Here we show that oyster larvae have higher survival to OsHV-1 when their mothers, but not their fathers, are exposed to poly(I:C) prior to spawning. RNA-seq provided no evidence to suggest that parental exposure to poly(I:C) reconfigures antiviral gene expression in unchallenged larvae. We conclude that the improved survival of larvae might occur via maternal provisioning of antiviral compounds in the eggs.

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Lafont Maxime, Goncalves Priscila, Guo Ximing, Montagnani Caroline, Raftos David, Green Timothy (2019). Transgenerational plasticity and antiviral immunity in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus 1 (OsHV-1). Developmental And Comparative Immunology, 91, 17-25. Publisher's official version : https://doi.org/10.1016/j.dci.2018.09.022 , Open Access version : https://archimer.ifremer.fr/doc/00459/57033/