The first release of SeaDataCloud Temperature and Salinity Historical Data Collection for the Mediterranean Sea (SDC_MED_DATA_TS_V1) includes open access in situ data of water column temperature and salinity between -9.25 and 37 degrees of longitude, thus including an Atlantic box and the Marmara Sea. The collection has been obtained harvesting all measurements contained within SeaDataNet infrastructure at the end of October 2017 belonging to 27 data providers (distributors) 111 data originators. The dataset format is Ocean Data View (ODV) binary collection. The quality control of the data has been performed using ODV 5.0 software. Data Quality Flags have been revised following SeaDataNet2 project QC procedures in conjunction with the visual expert check. The number of the Temperature and Salinity profiles (stations) in the collection is 739784.