Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters
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Date | 2018-10 | ||||||||||||||||||||||||||||||||||||||||||||
Language | English | ||||||||||||||||||||||||||||||||||||||||||||
Author(s) | de Lorgeril Julien1, Lucasson Aude1, Petton Bruno2, Toulza Eve1, Montagnani Caroline1, Clerissi Camille1, Vidal-Dupiol Jeremie1, Chaparro Cristian1, Galinier Richard1, Escoubas Jean Michel1, Haffner Philippe1, Degremont Lionel3, Charriere Guillaume1, Lafont Maxime1, Delort Abigail1, Vergnes Agnes1, Chiarello Marlene4, Faury Nicole3, Rubio Tristan1, Leroy Marc1, Perignon Adeline5, Regler Denis5, Morga Benjamin3, Alunno-Bruscia Marianne2, Boudry Pierre6, Le Roux Frederique7, Destoumieux-Garzon Delphine1, Gueguen Yannick1, Mitta Guillaume1 | ||||||||||||||||||||||||||||||||||||||||||||
Affiliation(s) | 1 : Univ Perpignan, Univ Montpellier, IFREMER, IHPE,CNRS, Via Domitia,Pl E Bataillon, F-34095 Montpellier, France. 2 : UBO, CNRS, IRD, LEMAR UMR 6539,Ifremer, 11 Presquile Vivier, F-29840 Argenton En Landunvez, France. 3 : IFREMER, Lab Genet & Pathol Mollusques Marins, Ave Mus de Loup, F-17930 La Tremblade, France. 4 : Univ Montpellier, CNRS, IFREMER, Marine Biodivers Exploitat & Conservat MARBEC,IR, Pl E Bataillon, F-34095 Montpellier, France. 5 : CRCM, Com Conchyliculture Mediterranee, F-34140 Meze, France. 6 : UBO, IRD, IFREMER, LEMAR UMR6539,CNRS, ZI Pointe Diable,CS 10070, F-29280 Plouzane, France. 7 : UPMC Paris 06, Sorbonne Univ, CNRS, UMR 8227,LBI2M,Ifremer,Stn Biol Roscoff, CS 90074, F-29680 Roscoff, France. |
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Source | Nature Communications (2041-1723) (Nature Publishing Group), 2018-10 , Vol. 9 , N. 4215 , P. 14p. | ||||||||||||||||||||||||||||||||||||||||||||
DOI | 10.1038/s41467-018-06659-3 | ||||||||||||||||||||||||||||||||||||||||||||
WOS© Times Cited | 170 | ||||||||||||||||||||||||||||||||||||||||||||
Abstract | Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly in fluenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 μVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. |
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