FN Archimer Export Format
PT J
TI Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters
BT 
AF DE LORGERIL, Julien
   LUCASSON, Aude
   PETTON, Bruno
   TOULZA, Eve
   MONTAGNANI, Caroline
   CLERISSI, Camille
   VIDAL-DUPIOL, Jeremie
   CHAPARRO, Cristian
   GALINIER, Richard
   ESCOUBAS, Jean Michel
   HAFFNER, Philippe
   DEGREMONT, Lionel
   CHARRIERE, Guillaume
   LAFONT, Maxime
   DELORT, Abigail
   VERGNES, Agnes
   CHIARELLO, Marlene
   FAURY, Nicole
   RUBIO, Tristan
   LEROY, Marc
   PERIGNON, Adeline
   REGLER, Denis
   MORGA, Benjamin
   ALUNNO-BRUSCIA, Marianne
   BOUDRY, Pierre
   LE ROUX, Frederique
   DESTOUMIEUX-GARZON, Delphine
   GUEGUEN, Yannick
   MITTA, Guillaume
AS 1:1;2:1;3:2;4:1;5:1;6:1;7:1;8:1;9:1;10:1;11:1;12:3;13:1;14:1;15:1;16:1;17:4;18:3;19:1;20:1;21:5;22:5;23:3;24:2;25:6;26:7;27:1;28:1;29:1;
FF 1:PDG-RBE-IHPE;2:;3:PDG-RBE-PFOM-LPI;4:;5:PDG-RBE-IHPE;6:PDG-RBE-IHPE;7:PDG-RBE-IHPE;8:;9:;10:;11:PDG-RBE-IHPE;12:PDG-RBE-SGMM-LGPMM;13:;14:;15:PDG-RBE-IHPE;16:PDG-RBE-IHPE;17:;18:PDG-RBE-SGMM-LGPMM;19:;20:;21:;22:;23:PDG-RBE-SGMM-LGPMM;24:PDG-RBE-PFOM-LPI;25:PDG-RBE-PFOM;26:PDG-RBE-PFOM;27:;28:PDG-RBE-IHPE;29:;
C1 Univ Perpignan, Univ Montpellier, IFREMER, IHPE,CNRS, Via Domitia,Pl E Bataillon, F-34095 Montpellier, France.
   UBO, CNRS, IRD, LEMAR UMR 6539,Ifremer, 11 Presquile Vivier, F-29840 Argenton En Landunvez, France.
   IFREMER, Lab Genet & Pathol Mollusques Marins, Ave Mus de Loup, F-17930 La Tremblade, France.
   Univ Montpellier, CNRS, IFREMER, Marine Biodivers Exploitat & Conservat MARBEC,IR, Pl E Bataillon, F-34095 Montpellier, France.
   CRCM, Com Conchyliculture Mediterranee, F-34140 Meze, France.
   UBO, IRD, IFREMER, LEMAR UMR6539,CNRS, ZI Pointe Diable,CS 10070, F-29280 Plouzane, France.
   UPMC Paris 06, Sorbonne Univ, CNRS, UMR 8227,LBI2M,Ifremer,Stn Biol Roscoff, CS 90074, F-29680 Roscoff, France.
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   CNRS, FRANCE
   CRCM, FRANCE
   IFREMER, FRANCE
   UNIV PARIS 06, FRANCE
SI MONTPELLIER
   ARGENTON
   LA TREMBLADE
   BREST
   ROSCOFF
SE PDG-RBE-IHPE
   PDG-RBE-PFOM-LPI
   PDG-RBE-SGMM-LGPMM
   PDG-RBE-PFOM
UM LEMAR
   MARBEC
   IHPE
IN WOS Ifremer jusqu'en 2018
   DOAJ
   copubli-france
   copubli-univ-france
IF 11.878
TC 170
UR https://archimer.ifremer.fr/doc/00461/57234/59228.pdf
   https://archimer.ifremer.fr/doc/00461/57234/59289.pdf
   https://archimer.ifremer.fr/doc/00461/57234/59290.pdf
   https://archimer.ifremer.fr/doc/00461/57234/59291.pdf
   https://archimer.ifremer.fr/doc/00461/57234/59292.xlsx
   https://archimer.ifremer.fr/doc/00461/57234/59293.xlsx
   https://archimer.ifremer.fr/doc/00461/57234/59294.xlsx
   https://archimer.ifremer.fr/doc/00461/57234/59295.xlsx
   https://archimer.ifremer.fr/doc/00461/57234/59296.xlsx
   https://archimer.ifremer.fr/doc/00461/57234/59297.xlsx
LA English
DT Article
AB Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly in fluenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 μVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. 
PY 2018
PD OCT
SO Nature Communications
SN 2041-1723
PU Nature Publishing Group
VL 9
IS 4215
UT 000447075700003
DI 10.1038/s41467-018-06659-3
ID 57234
ER

EF