Population-specific variations of the genetic architecture of sex determination in wild European sea bass Dicentrarchus labrax L.

Type Article
Date 2019-05
Language English
Author(s) Faggion Sara1, 2, Vandeputte Marc2, 3, Chatain Beatrice2, Gagnaire Pierre-Alexandre4, Allal FrancoisORCID2
Affiliation(s) 1 : Department of Comparative Biomedicine and Food Science, University of Padua, Agripolis, Viale dell’Università, 16, 35020 Legnaro, PD, Italy
2 : MARBEC, Univ. Montpellier, Ifremer, CNRS, IRD, Palavas-les- Flots, France
3 : GABI, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en- Josas, 78350 Paris, France
4 : ISEM, Univ. Montpellier, CNRS, IRD, EPHE, Montpellier, France
Source Heredity (0018-067X) (Springer Nature America, Inc), 2019-05 , Vol. 122 , N. 5 , P. 612-621
DOI 10.1038/s41437-018-0157-z
WOS© Times Cited 5
Abstract

Polygenic sex determination (PSD) may show variations in terms of genetic and environmental components between populations of fish species exposed/adapted to different environments. The European sea bass (Dicentrarchus labrax) is an interesting model, combining both a PSD system and a genetic subdivision into an Atlantic and a Mediterranean lineage, with genetic substructures within the Mediterranean Sea. Here, we produced experimental progeny crosses (N = 927) from broodstock sampled in four wild populations (North Atlantic, NAT; Western Mediterranean, WEM; North-Eastern Mediterranean, NEM; South-Eastern Mediterranean, SEM). We found less females than males in the progeny, both in the global dataset (32.5%) and within each paternal group (from 25.1% for NEM to 39.0% for WEM), with significant variation among populations, dams, and sires. Sex, body weight (BW), and body length (BL) showed moderate heritability (0.52 ± 0.17, 0.46 ± 0.17, 0.34 ± 0.15, respectively) and sex was genetically correlated with BW and BL, with rAsex/BW = 0.69 ± 0.12 and rA sex/BL = 0.66 ± 0.13. A weighted GWAS performed both on the global dataset and within each paternal group revealed a different genetic architecture of sex determination between Atlantic and Mediterranean populations (9 QTLs found in NAT, 7 in WEM, 5 in NEM, and 4 in SEM, with a cumulated variance explained of 27.04%, 21.87%, 15.89%, and 12.10%, respectively) and a more similar genetic architecture among geographically close populations compared to geographically distant populations, consistent with the hypothesis of a population-specific evolution of polygenic sex determination systems in different environments.

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