FN Archimer Export Format
PT J
TI Ocean warming combined with lower omega-3 nutritional availability impairs the cardio-respiratory function of a marine fish
BT 
AF Vagner, Marie
   Pante, Eric
   Viricel, Amelia
   Lacoue-Labarthe, Thomas
   ZAMBONINO-INFANTE, Jose-Luis
   Quazuguel, Patrick
   Dubillot, Emmanuel
   Huet, Valerie
   Le Delliou, Herve
   Lefrançois, Christel
   Imbert-Auvray, Nathalie
AS 1:1;2:1;3:1;4:1;5:2;6:2;7:1;8:1;9:2;10:1;11:1;
FF 1:;2:;3:;4:;5:PDG-RBE-PFOM-LARN;6:PDG-RBE-PFOM-LARN;7:;8:;9:PDG-RBE-PFOM-LARN;10:;11:;
C1 UMR 7266 LIENSs (University of La Rochelle – CNRS), 2 rue Olympe de Gouges 17000 La Rochelle, France
   Ifremer, UMR 6539 LEMAR, Center Ifremer ZI Pointe du diable 29280 Plouzané, France
C2 CNRS, FRANCE
   IFREMER, FRANCE
SI BREST
SE PDG-RBE-PFOM-LARN
UM LEMAR
IN WOS Ifremer UMR
   copubli-france
IF 3.014
TC 9
UR https://archimer.ifremer.fr/doc/00476/58744/63565.pdf
   https://archimer.ifremer.fr/doc/00476/58744/63566.pdf
LA English
DT Article
DE ;Omega-3 highly unsaturated fatty acids;Temperature;Cardiac performance;Swimming performance;Chelon auratus;RNAseq
AB Highly unsaturated fatty acids of the omega-3 series (HUFA) are major constituents of cell membranes, yet poorly synthesised de novo by consumers. Their production, mainly supported by aquatic microalgae, has been decreasing with global change. Understanding the consequences of such reductions is essential for ectotherm consumers, since temperature tightly regulates the HUFA content in cell membranes, maintaining their functionality. Integrating individual, tissue and molecular approaches, we examined the consequences of the combined effects of temperature and HUFA depletion on the key cardio-respiratory functions of the golden grey mullet, an ectotherm grazer of high ecological importance. For four months, fish were exposed to two contrasting HUFA diets (4.8% ecosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) on dry matter (DM) vs. 0.2% EPA+DHA on DM) at 12°C and 20°C. Ventricular force development coupled with gene expression profiles measured on cardiac muscle suggest that combining HUFA depletion with warmer temperatures leads to (1) a proliferation of sarcolemmal and SR Ca2+ channels and (2) a higher force-generating ability by increasing extracellular Ca2+ influx via sarcolemmal channels when the heart has to sustain excessive effort due to stress and/or exercise. At the individual scale, these responses were associated with a relatively greater aerobic scope, maximum metabolic rate and net cost of locomotion, suggesting the higher energy cost of this strategy. These impaired cardiac performances could have wider consequences on other physiological performances such as growth, reproduction or migration, all greatly depending on heart function. 
PY 2019
PD APR
SO Journal Of Experimental Biology
SN 0022-0949
PU The Company of Biologists
VL 222
IS 8
UT 000466766400002
DI 10.1242/jeb.187179
ID 58744
ER

EF