FN Archimer Export Format
PT J
TI Marine Polysaccharide-Collagen Coatings on Ti6Al4V Alloy Formed by Self-Assembly
BT 
AF Norris, Karl
   Mishukova, Oksana
   Zykwinska, Agata
   Colliec-Jouault, Sylvia
   Sinquin, Corinne
   Koptioug, Andrei
   Cuenot, Stéphane
   Kerns, Jemma
   Surmeneva, Maria
   Surmenev, Roman
   Douglas, Timothy
AS 1:1;2:2;3:3;4:3;5:3;6:4;7:5;8:6;9:2;10:2;11:1,7;
FF 1:;2:;3:PDG-RBE-BRM-LEMMMB;4:PDG-RBE-BRM-LEMMMB;5:PDG-RBE-BRM-LEMMMB;6:;7:;8:;9:;10:;11:;
C1 Engineering Department, Lancaster University, Lancaster LA1 4YW, UK
   Physical Materials Science and Composite Materials Centre, National research Tomsk Polytechnic University, Tomsk 634050, Russia
   IFREMER, Laboratoire Ecosystèmes Microbiens et Molécules Marines pour les Biotechnologies, F-44311 Nantes, France
   Sports Tech Research Centre, Mid-Sweden University, Akademigatan 1, 83125 Östersund, Sweden
   Institut des Matériaux Jean Rouxel (IMN), Université de Nantes-CNRS, 44322 Nantes, France
   Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YW, UK
   Materials Science Institute (MSI), Lancaster University, Lancaster LA1 4YW, UK
C2 UNIV LANCASTER, UK
   UNIV TOMSK, RUSSIA
   IFREMER, FRANCE
   UNIV OSTERSUND, SWEDEN
   UNIV NANTES, FRANCE
   UNIV LANCASTER, UK
   UNIV LANCASTER, UK
SI NANTES
SE PDG-RBE-BRM-LEMMMB
IN WOS Ifremer UPR
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
   copubli-int-hors-europe
IF 1.286
TC 10
UR https://archimer.ifremer.fr/doc/00477/58881/61433.pdf
   https://archimer.ifremer.fr/doc/00477/58881/61434.pdf
LA English
DT Article
DE ;marine exopolysaccharide;collagen;surface modification;Ti6Al4V
AB Polysaccharides of marine origin are gaining interest as biomaterial components. Bacteria derived from deep-sea hydrothermal vents can produce sulfated exopolysaccharides (EPS), which can influence cell behavior. The use of such polysaccharides as components of organic, collagen fibril-based coatings on biomaterial surfaces remains unexplored. In this study, collagen fibril coatings enriched with HE800 and GY785 EPS derivatives were deposited on titanium alloy (Ti6Al4V) scaffolds produced by rapid prototyping and subjected to physicochemical and cell biological characterization. Coatings were formed by a self-assembly process whereby polysaccharides were added to acidic collagen molecule solution, followed by neutralization to induced self-assembly of collagen fibrils. Fibril formation resulted in collagen hydrogel formation. Hydrogels formed directly on Ti6Al4V surfaces, and fibrils adsorbed onto the surface. Scanning electron microscopy (SEM) analysis of collagen fibril coatings revealed association of polysaccharides with fibrils. Cell biological characterization revealed good cell adhesion and growth on bare Ti6Al4V surfaces, as well as coatings of collagen fibrils only and collagen fibrils enhanced with HE800 and GY785 EPS derivatives. Hence, the use of both EPS derivatives as coating components is feasible. Further work should focus on cell differentiation 
PY 2019
PD JAN
SO Micromachines
SN 2072-666X
PU MDPI AG
VL 10
IS 1
UT 000459735300067
DI 10.3390/mi10010068
ID 58881
ER

EF