FN Archimer Export Format PT J TI Harmful or harmless: biological effects of marennine on marine organisms BT AF Falaise, Charlotte Cormier, Patrick Tremblay, Réjean Audet, Céline Deschênes, Jean-Sébastien Turcotte, François François, Cyrille Seger, Andreas Hallegraeff, Gustaaf Lindquist, Niels Sirjacobs, Damien Gobert, Sylvie Lejeune, Pierre Demoulin, Vincent Mouget, Jean-Luc AS 1:1;2:2;3:3;4:3;5:3;6:3;7:4;8:5,6;9:5;10:7;11:8;12:9,10;13:10;14:8;15:1; FF 1:;2:;3:;4:;5:;6:;7:PDG-RBE-SGMM-LGPMM;8:;9:;10:;11:;12:;13:;14:;15:; C1 Laboratoire Mer Molécule Santé (EA 2160, FR CNRS 3473 IUML), Le Mans Université, Le Mans, France Sorbonne Universités (UPMC Paris 06, CNRS, UMR 8227) Biologie Intégrative des Modèles Marins, Station Biologique de Roscoff, Roscoff, France Institut des sciences de la mer, Université du Québec à Rimouski, Rimouski, Canada Ifremer, RBE-SG2M-LGPMM, Laboratoire de Génétique et de Pathologie des Mollusques Marins, Station La Tremblade, Avenue Mus Loup, F-17390 La Tremblade, France Institute for Marine and Antarctic Studies (IMAS), University of Tasmania, Hobart, Australia South Australian Research and Development Institute (SARDI), Urrbrae, South Australia Institute of Marine Sciences, University of North Carolina, Chapel Hill, United States INBIOS - PHYTOSYSTEMS, Eukaryotic Phylogenomics, Liège University, Liège, Belgium Université de Liège, MARE, Focus, Océanologie Biologique, Liège, Belgium Station de Recherche Sous-marines et Océanographiques (STARESO), 20260 Calvi, France C2 UNIV LE MANS, FRANCE UNIV PARIS 06, FRANCE UNIV QUEBEC (UQAR-ISMER), CANADA IFREMER, FRANCE UNIV TASMANIA, AUSTRALIA SARDI, AUSTRALIA UNIV NORTH CAROLINA CHAPEL HILL, USA UNIV LIEGE, BELGIUM UNIV LIEGE, BELGIUM STARESO, FRANCE SI LA TREMBLADE SE PDG-RBE-SGMM-LGPMM IN WOS Ifremer UPR copubli-france copubli-europe copubli-univ-france copubli-int-hors-europe IF 4.344 TC 10 UR https://archimer.ifremer.fr/doc/00477/58887/61443.pdf LA English DT Article DE ;Diatom;Haslea ostrearia;Marennine;Marine organisms;Natural bioactive compound AB Marennine is a water-soluble blue-green pigment produced by the marine diatom Haslea ostrearia. The diatom and its pigment are well known from oyster farming areas as the source of the greening of oyster gills, a natural process increasing their market value in Western France. Blooms of blue Haslea are also present outside oyster ponds and hence marine organisms can be exposed, periodically and locally, to significant amounts of marennine in natural environments. Due to its demonstrated antibacterial activities against marine pathogenic bacteria (e.g. Vibrio) and possible prophylactic effects toward bivalve larvae, marennine is of special interest for the aquaculture industry, especially bivalve hatcheries. The present study aimed to provide new insights into the effects of marennine on a large spectrum of marine organisms belonging to different phyla, including species of aquaculture interest and organisms frequently employed in standardised ecotoxicological assays. Different active solutions containing marennine were tested: partially purified Extracellular Marennine (EMn), and concentrated solutions of marennine present in H. ostrearia culture supernatant; the Blue Water (BW) and a new process called Concentrated Supernatant (CS). Biological effects were meanwhile demonstrated in invertebrate species for the three marennine-based solutions at the highest concentrations tested (e.g., decrease of fertilization success, delay of embryonic developmental stages or larval mortality). Exposure to low concentrations did not impact larval survival or development and even tended to enhance larval physiological state. Furthermore, no effects of marennine were observed on the fish gill cell line tested. Marennine could be viewed as a Jekyll and Hyde molecule, which possibly affects the earliest stages of development of some organisms but with no direct impacts on adults. Our results emphasize the need to determine dosages that optimize beneficial effects and critical concentrations not to be exceeded before considering the use of marennine in bivalve or fish hatcheries. PY 2019 PD APR SO Aquatic Toxicology SN 0166-445X PU Elsevier BV VL 209 UT 000462420600002 BP 13 EP 25 DI 10.1016/j.aquatox.2019.01.016 ID 58887 ER EF