FN Archimer Export Format
PT J
TI Epigenetically facilitated mutational assimilation: epigenetics as a hub within the inclusive evolutionary synthesis
BT 
AF DANCHIN, Etienne
   POCHEVILLE, Arnaud
   REY, Olivier
   PUJOL, Benoit
   BLANCHET, Simon
AS 1:1;2:1,2,3;3:4,5;4:1;5:1,4;
FF 1:;2:;3:;4:;5:;
C1 Univ Toulouse Midi Pyrenees, Lab Evolut & Diversite Biol, CNRS, EDB UMR 5174,IRD,UPS, 118 Route Narbonne,Bat 4R1, F-31062 Toulouse 9, France.
   Univ Sydney, Dept Philosophy, Sydney, NSW 2006, Australia.
   Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia.
   SETE, CNRS, UMR5321, F-09200 Moulis, France.
   Univ Montpellier, Univ Perpignan, IFREMER, CNRS,IHPE UMR 5244, Via Domitia, F-66860 Perpignan, France.
C2 UNIV TOULOUSE, FRANCE
   UNIV SYDNEY, AUSTRALIA
   UNIV SYDNEY, AUSTRALIA
   CNRS, FRANCE
   UNIV PERPIGNAN, FRANCE
UM IHPE
IN WOS Cotutelle UMR
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 10.701
TC 62
UR https://archimer.ifremer.fr/doc/00479/59037/62430.pdf
   https://archimer.ifremer.fr/doc/00479/59037/62431.pdf
LA English
DT Article
DE ;non-genetic inheritance;inclusive heritability;epigenetics;central dogma;genetic assimilation;mutation randomness;inclusive evolutionary synthesis
AB After decades of debate about the existence of non-genetic inheritance, the focus is now slowly shifting towards dissecting its underlying mechanisms. Here, we propose a new mechanism that, by integrating non-genetic and genetic inheritance, may help build the long-sought inclusive vision of evolution. After briefly reviewing the wealth of evidence documenting the existence and ubiquity of non-genetic inheritance in a table, we review the categories of mechanisms of parent-offspring resemblance that underlie inheritance. We then review several lines of argument for the existence of interactions between non-genetic and genetic components of inheritance, leading to a discussion of the contrasting timescales of action of non-genetic and genetic inheritance. This raises the question of how the fidelity of the inheritance system can match the rate of environmental variation. This question is central to understanding the role of different inheritance systems in evolution. We then review and interpret evidence indicating the existence of shifts from inheritance systems with low to higher transmission fidelity. Based on results from different research fields we propose a conceptual hypothesis linking genetic and non-genetic inheritance systems. According to this hypothesis, over the course of generations, shifts among information systems allow gradual matching between the rate of environmental change and the inheritance fidelity of the corresponding response. A striking conclusion from our review is that documented shifts between types of inherited non-genetic information converge towards epigenetics (i.e. inclusively heritable molecular variation in gene expression without change in DNA sequence). We then interpret the well-documented mutagenicity of epigenetic marks as potentially generating a final shift from epigenetic to genetic encoding. This sequence of shifts suggests the existence of a relay in inheritance systems from relatively labile ones to gradually more persistent modes of inheritance, a relay that could constitute a new mechanistic basis for the long-proposed, but still poorly documented, hypothesis of genetic assimilation. A profound difference between the genocentric and the inclusive vision of heredity revealed by the genetic assimilation relay proposed here lies in the fact that a given form of inheritance can affect the rate of change of other inheritance systems. To explore the consequences of such inter-connection among inheritance systems, we briefly review published theoretical models to build a model of genetic assimilation focusing on the shift in the engraving of environmentally induced phenotypic variation into the DNA sequence. According to this hypothesis, when environmental change remains stable over a sufficient number of generations, the relay among inheritance systems has the potential to generate a form of genetic assimilation. In this hypothesis, epigenetics appears as a hub by which non-genetically inherited environmentally induced variation in traits can become genetically encoded over generations, in a form of epigenetically facilitated mutational assimilation. Finally, we illustrate some of the major implications of our hypothetical framework, concerning mutation randomness, the central dogma of molecular biology, concepts of inheritance and the curing of inherited disorders, as well as for the emergence of the inclusive evolutionary synthesis. 
PY 2019
PD FEB
SO Biological Reviews
SN 1464-7931
PU Wiley
VL 94
IS 1
UT 000456071400014
BP 259
EP 282
DI 10.1111/brv.12453
ID 59037
ER

EF