Complex Relationships between the Blue Pigment Marennine and Marine Bacteria of the Genus Vibrio

Type Article
Date 2019-03
Language English
Other localization https://www.mdpi.com/1660-3397/17/3/160/htm
Author(s) Falaise Charlotte1, James Adele2, 3, Travers Marie-AgnesORCID4, Zanella Marie1, Badawi Myriam1, Mouget Jean-Luc1
Affiliation(s) 1 : Laboratoire Mer Molécule Santé (EA 2160, FR CNRS 3473 IUML, Le Mans Université, F-72-000 Le Mans, France
2 : IFREMER, PDG-RBE-PFOM-LPI, Centre Bretagne, ZI de la Pointe du Diable, CS 10070, F-29280 Plouzané, France
3 : Sorbonne Université (UPMC Paris 06, CNRS, UMR 8227), Laboratoire de Biologie Intégrative des Modèles Marins, Station Biologique de Roscoff, F-26680 Roscoff, France
4 : IFREMER, PDG-RBE-SG2M-LGPMM, Station de La Tremblade, Ronce Les Bains, F-17390 La Tremblade, France
Source Marine Drugs (1660-3397) (MDPI AG), 2019-03 , Vol. 17 , N. 3 , P. 160 (12p.)
DOI 10.3390/md17030160
WOS© Times Cited 4
Note This article belongs to the Special Issue Marine Bacteria as Sources of Bioactive Compounds
Keyword(s) antibacterial activity, diauxie, Haslea, hormesis, marennine, Vibrio
Abstract

Marennine, the water-soluble blue pigment produced by the marine diatom Haslea ostrearia, is known to display antibacterial activities. Previous studies have demonstrated a prophylactic effect of marennine on bivalve larvae challenged with a pathogenic Vibrio splendidus, suggesting that the blue Haslea is a good candidate for applications in aquaculture as a source of a natural antimicrobial agent. Indeed, the genus Vibrio is ubiquitous in aquaculture ecosystems, and regular events of pathogenic invasion cause some of the biggest losses worldwide. To better characterize the effects of marennine on Vibrios, a panel of 30 Vibrio strains belonging to 10 different species was tested, including bivalve pathogenic species (e.g., Vibrio crassostreae and Vibrio harveyi). Vibrio strains were first exposed to 10 and 25 µg mL−1 of Blue Water (BW), a concentrated culture supernatant of H. ostrearia containing marennine. This screening evidenced a great diversity in responses, from growth stimulation to a total inhibition, at both the interspecific or intraspecific level. In a second series of experiments, 10 Vibrio strains were exposed to BW at concentrations ranging from 5 to 80 µg mL−1. The highest concentrations of BW did not systematically result in the highest growth inhibition as hormetic responses—opposite effects regarding the concentration—were occasionally evidenced. The relationships between marennine and Vibrio strains appear more complex than expected and justify further study—in particular, on the mechanisms of action—before considering applications as a natural prophylactic or antibiotic agent in aquaculture

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