FN Archimer Export Format PT J TI The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms BT AF PEREZ-PASCUAL, David LUNAZZI, Aurelie MAGDELENAT, Ghislaine ROUY, Zoe ROULET, Alain LOPEZ-ROQUES, Celine LAROCQUE, Robert BARBEYRON, Tristan GOBET, Angelique MICHEL, Gurvan BERNARDET, Jean-Francois DUCHAUD, Eric AS 1:1;2:1;3:2;4:3;5:4,5;6:4,5;7:6;8:6;9:6;10:6;11:1;12:1; FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:; C1 Univ Paris Saclay, INRA, Virol & Immunol Mol, Jouy En Josas, France. Genoscope, Inst Genom, Commissiariat Energie Atom & Energies Alternat, Evry, France. Genoscope, Inst Genom, Commissariat Energie Atom & Energies Alternat, CNRS,UMR 8030,Lab Anal Bioinformat Genom & Met, Evry, France. INRA, Genotoul Genome & Transcriptome GeT PlaGe, Castanet Tolosan, France. INRA, UAR1209, Castanet Tolosan, France. Sorbonne Univ, Stn Biol Roscoff, Univ Pierre & Marie Curie, CNRS,UMR 8227,Lab Biol Integrat Modeles Marins, Roscoff, France. C2 UNIV PARIS SACLAY, FRANCE GENOSCOPE, FRANCE CNRS, FRANCE INRA, FRANCE INRA, FRANCE UNIV PARIS 06, FRANCE IF 4.019 TC 47 UR https://archimer.ifremer.fr/doc/00488/59939/63150.pdf https://archimer.ifremer.fr/doc/00488/59939/63151.pdf https://archimer.ifremer.fr/doc/00488/59939/63152.pdf https://archimer.ifremer.fr/doc/00488/59939/63153.pdf https://archimer.ifremer.fr/doc/00488/59939/63154.pdf https://archimer.ifremer.fr/doc/00488/59939/63155.pdf https://archimer.ifremer.fr/doc/00488/59939/63156.pdf https://archimer.ifremer.fr/doc/00488/59939/63157.pdf LA English DT Article DE ;Tenacibaculum maritimum;fish pathogen;virulence factors;genome;toxins AB Tenacibaculum maritimum is a devastating bacterial pathogen of wild and farmed marine fish with a broad host range and a worldwide distribution. We report here the complete genome sequence of the T. maritimum type strain NCIMB 2154(T). The genome consists of a 3,435,971-base pair circular chromosome with 2,866 predicted protein-coding genes. Genes encoding the biosynthesis of exopolysaccharides, the type IX secretion system, iron uptake systems, adhesins, hemolysins, proteases, and glycoside hydrolases were identified. They are likely involved in the virulence process including immune escape, invasion, colonization, destruction of host tissues, and nutrient scavenging. Among the predicted virulence factors, type IX secretion-mediated and cell-surface exposed proteins were identified including an atypical sialidase, a sphingomyelinase and a chondroitin AC lyase which activities were demonstrated in vitro. PY 2017 PD AUG SO Frontiers In Microbiology SN 1664-302X PU Frontiers Media Sa VL 8 IS 1542 UT 000407741600001 DI 10.3389/fmicb.2017.01542 ID 59939 ER EF