FN Archimer Export Format
PT J
TI Tissue-Specific Biomarker Responses in the Blue Mussel Mytilus spp. Exposed to a Mixture of Microplastics at Environmentally Relevant Concentrations
BT 
AF Revel, Messika
   Lagarde, Fabienne
   Perrein-Ettajani, Hanane
   Bruneau, Mélanie
   Akcha, Farida
   Sussarellu, Rossana
   Rouxel, Julien
   Costil, Katherine
   Decottignies, Priscilla
   Cognie, Bruno
   Châtel, Amélie
   Mouneyrac, Catherine
AS 1:1;2:2;3:1;4:1;5:3;6:3;7:3;8:4;9:5;10:5;11:1;12:1;
FF 1:;2:;3:;4:;5:PDG-RBE-BE-LEX;6:PDG-RBE-BE-LEX;7:PDG-RBE-BE-LEX;8:;9:;10:;11:;12:;
C1 Laboratoire Mer, Molécules, Santé (MMS EA2160), Université Catholique de l'Ouest, Angers, France
   Institut des Molécules et des Matériaux du Mans, UMR CNRS 6283, Le Mans Université, Le Mans, France
   Ifremer, Laboratoire d'Ecotoxicologie, Nantes, France
   UMR BOREA, MNHN, UPMC, UCBN, CNRS-7208, IRD-207, SFR ICORE, Université de Caen Normandie, Caen, France
   FR CNRS 3473 IUML, Laboratoire Mer, Molécules, Santé (MMS EA2160), Université de Nantes, Nantes, France
C2 UNIV CATHOLIQUE OUEST, FRANCE
   UNIV LE MANS, FRANCE
   IFREMER, FRANCE
   UNIV CAEN, FRANCE
   UNIV NANTES, FRANCE
SI NANTES
SE PDG-RBE-BE-LEX
IN WOS Ifremer UPR
   DOAJ
   copubli-france
   copubli-univ-france
IF 5.411
TC 86
UR https://archimer.ifremer.fr/doc/00489/60089/63427.pdf
   https://archimer.ifremer.fr/doc/00489/60089/63428.tif
   https://archimer.ifremer.fr/doc/00489/60089/63429.tif
   https://archimer.ifremer.fr/doc/00489/60089/63430.tif
   https://archimer.ifremer.fr/doc/00489/60089/63431.tif
LA English
DT Article
DE ;microplastics;polyethylene;polypropylene;Mytilus;oxidative stress;biomarkers
AB The impact of a microplastic (MP) mixture composed of polyethylene (PE) and polypropylene (PP) plastic particles, prepared from commercially available products, was evaluated in blue mussels Mytilus spp. exposed to three environmentally relevant concentrations: 0.008 μg L−1 (low), 10 μg L−1 (medium), and 100 μg L−1 (high). Organisms were exposed for 10 days followed by 10 days of depuration in clean seawater under controlled laboratory conditions. The evaluation of MP effects on mussel clearance rate, tissue structure, antioxidant defenses, immune and digestive parameters, and DNA integrity were investigated while the identification of plastic particles in mussel tissues (gills, digestive gland, and remaining tissues), and biodeposits (feces and pseudofaeces) was performed using infrared microscopy (μFT-IR). Results showed the presence of MPs only in the digestive gland of mussels exposed to the highest tested concentration of MPs with a mean of 0.75 particle/mussel (after the 10 days of exposure). In biodeposits, PE and PP particles were detected following exposure to all tested concentrations confirming the ingestion of MPs by the organisms. A differential response of antioxidant enzyme activities between digestive gland and gills was observed. Significant increases in superoxide dismutase (SOD) and catalase (CAT) activities were measured in the digestive gland of mussels exposed to the low (0.008 μg L−1) and medium (10 μg L−1) concentrations of MPs and in the gills from mussels exposed to the highest concentration (100 μg L−1) of MPs that could be indicative of a change in the redox balance. Moreover, an increase in acid phosphatase activity was measured in hemolymph of mussels exposed to 0.008 and 10 μg L−1 concentrations. No significant difference was observed in the clearance rate, and histopathological parameters between control and exposed mussels. This study brings new insights on the potential sublethal impacts of MPs at environmentally relevant concentrations in marine bivalves. 
PY 2019
PD MAR
SO Frontiers In Environmental Science
SN 2296-665X
PU Frontiers Media SA
VL 7
IS 33
UT 000463683900002
DI 10.3389/fenvs.2019.00033
ID 60089
ER

EF