FN Archimer Export Format
PT J
TI Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?
BT 
AF CARVALHO, Raquel N.
   ARUKWE, Augustine
   AIT-AISSA, Selim
   BADO-NILLES, Anne
   BALZAMO, Stefania
   BAUN, Anders
   BELKIN, Shimshon
   BLAHA, Ludek
   BRION, Francois
   CONTI, Daniela
   CREUSOT, Nicolas
   ESSIG, Yona
   FERRERO, Valentina E. V.
   FLANDER-PUTRLE, Vesna
   FURHACKER, Maria
   GRILLARI-VOGLAUER, Regina
   HOGSTRAND, Christer
   JONAS, Adam
   KHARLYNGDOH, Joubert B.
   LOOS, Robert
   LUNDEBYE, Anne-Katrine
   MODIG, Carina
   OLSSON, Per-Erik
   PILLAI, Smitha
   POLAK, Natasa
   POTALIVO, Monica
   SANCHEZ, Wilfried
   SCHIFFERLI, Andrea
   SCHIRMER, Kristin
   SFORZINI, Susanna
   STURZENBAUM, Stephen R.
   SOFTELAND, Liv
   TURK, Valentina
   VIARENGO, Aldo
   WERNER, Inge
   YAGUR-KROLL, Sharon
   ZOUNKOVA, Radka
   LETTIERI, Teresa
AS 1:1;2:2;3:3;4:3,4;5:5;6:6;7:7;8:8;9:3;10:5;11:3;12:9;13:1;14:10;15:11;16:11;17:12;18:8;19:13;20:1;21:14;22:13;23:13;24:11;25:9;26:5;27:3;28:16;29:15,17,18;30:19;31:9;32:14;33:10;34:19;35:16;36:7;37:8;38:;
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C1 Commiss European Communities, DG Joint Res Ctr, Inst Environm & Sustainabil, I-21027 Ispra, VA, Italy.
   Norwegian Univ Sci & Technol, N-7034 Trondheim, Norway.
   Natl Inst Ind Environm & Risks, Verneuil En Halatte, France.
   Univ Reims, F-51100 Reims, France.
   ISPRA, Rome, Italy.
   Tech Univ Denmark, Dept Environm Engn, Lyngby, Denmark.
   Hebrew Univ Jerusalem, Inst Life Sci, IL-91905 Jerusalem, Israel.
   Masaryk Univ, Fac Sci, RECETOX, CS-61137 Brno, Czech Republic.
   Kings Coll London, Analyt & Environm Sci Div, London WC2R 2LS, England.
   Natl Inst Biol, Marine Biol Stn Piran, Ljubljana, Slovenia.
   Univ Nat Resources & Life Sci, Vienna, Austria.
   Kings Coll London, Diabet & Nutr Sci Div, London WC2R 2LS, England.
   Univ Orebro, Life Sci Ctr, Orebro, Sweden.
   Natl Inst Nutr & Seafood Res, Bergen, Norway.
   Eawag, Swiss Fed Inst Aquat Sci & Technol, Dubendorf, Switzerland.
   Eawag EPFL, Swiss Ctr Appl Ecotoxicol, Dubendorf, Switzerland.
   Swiss Fed Inst Technol, Dept Environm Syst Sci, Swiss Fed Inst Technol, Zurich, Switzerland.
   EPF Lausanne, Sch Architecture Civil & Environm Engn, Lausanne, Switzerland.
   Univ Piemonte Orientale Vercelli Novara Alessandr, Dept Environm & Life Sci, Alessandria, Italy.
C2 JRC, ITALY
   UNIV SCI & TECHNOL NORWEGIAN, NORWAY
   INERIS, FRANCE
   UNIV REIMS, FRANCE
   ISPRA, ITALY
   UNIV TECH DENMARK, DENMARK
   UNIV HEBREW JERUSALEM, ISRAEL
   UNIV MASARYK, CZECH REPUBLIC
   KINGS COLL LONDON, UK
   NATL INST BIOL, SLOVENIA
   UNIV NAT RESOURCES & LIFE SCI, AUSTRIA
   KINGS COLL LONDON, UK
   UNIV OREBRO, SWEDEN
   NIFES, NORWAY
   EAWAG, SWITZERLAND
   EAWAG EPFL, SWITZERLAND
   ETH ZURICH, SWITZERLAND
   EPF LAUSANNE, SWITZERLAND
   UNIUPO, ITALY
IF 3.854
TC 79
UR https://archimer.ifremer.fr/doc/00499/61115/64667.pdf
   https://archimer.ifremer.fr/doc/00499/61115/64668.pdf
LA English
DT Article
DE ;bioassays;effects;mixtures;ecotoxicology;biomarkers
AB The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations. 
PY 2014
PD SEP
SO Toxicological Sciences
SN 1096-6080
PU Oxford Univ Press
VL 141
IS 1
UT 000342990200026
BP 218
EP 233
DI 10.1093/toxsci/kfu118
ID 61115
ER

EF