FN Archimer Export Format
PT J
TI Deep-sea Hydrothermal Vent Bacteria as a Source of Glycosaminoglycan-Mimetic Exopolysaccharides
BT 
AF ZYKWINSKA, Agata
   MARCHAND, Laetitia
   BONNETOT, Sandrine
   SINQUIN, Corinne
   COLLIEC-JOUAULT, Sylvia
   DELBARRE-LADRAT, Christine
AS 1:1;2:1;3:1;4:1;5:1;6:1;
FF 1:PDG-RBE-BRM-LEMMMB;2:PDG-RBE-BRM-LEMMMB;3:PDG-RBE-BRM-LEMMMB;4:PDG-RBE-BRM-LEMMMB;5:PDG-RBE-BRM-LEMMMB;6:PDG-RBE-BRM-LEMMMB;
C1 IFREMER, Lab Ecosyst Microbiens & Mol Marines Biotechnol, F-44311 Nantes, France.
C2 IFREMER, FRANCE
SI NANTES
SE PDG-RBE-BRM-LEMMMB
IN WOS Ifremer UPR
   DOAJ
IF 0.182
TC 13
UR https://archimer.ifremer.fr/doc/00506/61756/65728.pdf
   https://archimer.ifremer.fr/doc/00506/61756/65729.pdf
LA English
DT Article
DE ;exopolysaccharide;glycosaminoglycan;uronic acid;hexosamine;phylogenetic analysis
AB Bacteria have developed a unique strategy to survive in extreme environmental conditions through the synthesis of an extracellular polymeric matrix conferring upon the cells a protective microenvironment. The main structural component of this complex network constitutes high-molecular weight hydrophilic macromolecules, namely exopolysaccharides (EPS). EPS composition with the presence of particular chemical features may closely be related to the specific conditions in which bacteria evolve. Deep-sea hydrothermal vent bacteria have already been shown to produce EPS rich in hexosamines and uronic acids, frequently bearing some sulfate groups. Such a particular composition ensures interesting functional properties, including biological activities mimicking those known for glycosaminoglycans (GAG). The aim of the present study was to go further into the exploration of the deep-sea hydrothermal vent IFREMER (French Research Institute for Exploitation of the Sea) collection of bacteria to discover new strains able to excrete EPS endowed with GAG-like structural features. After the screening of our whole collection containing 692 strains, 38 bacteria have been selected for EPS production at the laboratory scale. EPS-producing strains were identified according to 16S rDNA phylogeny. Chemical characterization of the obtained EPS highlighted their high chemical diversity with the presence of atypical compositional patterns. These EPS constitute potential bioactives for a number of biomedical applications, including regenerative medicines and cancer treatment. 
PY 2019
PD MAY
SO Molecules
SN 1420-3049
PU Mdpi
VL 24
IS 9
UT 000469518100062
DI 10.3390/molecules24091703
ID 61756
ER

EF