FN Archimer Export Format
PT J
TI Pinnatoxins’ Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health
BT 
AF Delcourt, Nicolas
   Lagrange, Emmeline
   Abadie, Eric
   Fessard, Valérie
   Frémy, Jean-Marc
   Vernoux, Jean-Paul
   Peyrat, Marie-Bénédicte
   Maignien, Thomas
   Arnich, Nathalie
   Molgó, Jordi
   Mattei, César
AS 1:1;2:2;3:3;4:4;5:5;6:6;7:7;8:7;9:7;10:8,9;11:10;
FF 1:;2:;3:PDG-ODE-LITTORAL-LERLR;4:;5:;6:;7:;8:;9:;10:;11:;
C1 Poison Control Centre, Toulouse-Purpan University Hospital and Toulouse NeuroImaging Centre (ToNIC), INSERM1214, Toulouse-Purpan University Hospital, 31059 Toulouse, France
   Department of Neurology, Reference Center of Neuromuscular Disease, Grenoble University Hospital, 38000 Grenoble, France
   Laboratoire Environnement Ressources du Languedoc-Roussillon, Centre for Marine Biodiversity, Exploitation and Conservation (MARBEC), IRD, Institut Français de Recherche pour l’Exploitation de la Mer (Ifremer), CNRS, Université de Montpellier, CS30171, 34200 Sete Cedex 03, France
   Toxicology of Contaminants Unit, ANSES—French Agency for Food, Environmental and Occupational Health & Safety, 35306 Fougères, France
   Retired from ANSES—French Agency for Food, Environmental and Occupational Health & Safety, 94701 Maisons-Alfort, France
   Research Unit EA 4651 Aliments Bioprocédés Toxicologie Environnements (ABTE), Normandie University, 14000 Caen, France
   Risk Assessment Department, ANSES—French Agency for Food, Environmental and Occupational Health & Safety, 94701 Maisons-Alfort, France
   Institut des Sciences du Vivant Frédéric Joliot, Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), Commissariat à l’Energie Atomique et aux énergies alternatives (CEA) Saclay, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France
   Institut des Neurosciences Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), UMR 9197 CNRS/Université Paris-Sud, F-91198 Gif-sur-Yvette, France
   Mitochondrial and Cardiovascular Pathophysiology (MITOVASC), Cardiovascular Mechanotransduction, UMR CNRS 6015, INSERM U1083, Angers University, 49045 Angers, France
C2 INSERM, FRANCE
   UNIV GRENOBLE, FRANCE
   IFREMER, FRANCE
   ANSES, FRANCE
   ANSES, FRANCE
   UNIV NORMANDIE, FRANCE
   ANSES, FRANCE
   CEA, FRANCE
   CNRS, FRANCE
   UNIV ANGERS, FRANCE
SI SETE
SE PDG-ODE-LITTORAL-LERLR
UM MARBEC
IN WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 1.103
TC 12
UR https://archimer.ifremer.fr/doc/00507/61883/65958.pdf
LA English
DT Article
DE ;pinnatoxins;cyclic imines;Vulcanodinium rugosum;nicotinic acetylcholine receptors;acute neurotoxicity;human intoxication;myasthenia gravis
AB Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been reported to date although acute toxicity was induced by PnTxs in rodents. LD50 values have been estimated for the different PnTXs through the oral route. At sublethal doses, all symptoms are reversible, and no neurological sequelae are visible. These symptoms are consistent with impairment of central and peripheral cholinergic network functions. In fact, PnTXs are high-affinity competitive antagonists of nicotinic acetylcholine receptors (nAChRs). Moreover, their lethal effects are consistent with the inhibition of muscle nAChRs, inducing respiratory distress and paralysis. Human intoxication by ingestion of PnTXs could result in various symptoms observed in episodes of poisoning with natural nAChR antagonists. This review updates the available data on PnTX toxicity with a focus on their mode of action on cholinergic networks and suggests the effects that could be extrapolated on human physiology. 
PY 2019
PD JUN
SO Marine Drugs
SN 1660-3397
PU MDPI AG
VL 17
IS 7
UT 000478650600036
DI 10.3390/md17070425
ID 61883
ER

EF