FN Archimer Export Format
PT J
TI Effects of the Environment on Developmental Plasticity and Infection Success of Schistosoma Parasites - An Epigenetic Perspective
BT 
AF de Carvalho AUGUSTO, Ronaldo
   DUVAL, David
   GRUNAU, Christoph
AS 1:1,2;2:1;3:1;
FF 1:;2:;3:;
C1 Univ Perpignan Via Domitia, CNRS, IFREMER, IHPE UMR 5244, Perpignan, France.
   Univ Perpignan Via Domitia, CNRS, IFREMER, IHPE UMR 5244, Perpignan, France.
C2 UNIV PERPIGNAN, FRANCE
   CNRS, FRANCE
UM IHPE
IN WOS Cotutelle UMR
   DOAJ
IF 4.235
TC 13
UR https://archimer.ifremer.fr/doc/00508/61941/66028.pdf
LA English
DT Article
DE ;schistosomiasis;environmental cues;inheritance systems;imune response;host-para site interactions
AB Evidence of how environmental cues affect the phenotypes of, and compatibility between Schistosoma mansoni and their hosts come from studies in environmental parasitology and research on host diet and chemotherapeutic treatment. Schistosomes deal with a multitude of signals from the water environment as well as cues that come from their hosts, particularly in response to molecules that serve to recognize and destroy them, i.e., those molecules that arise from their hosts' immune systems. These interactions shape, not only the parasite's morphology, metabolism and behavior in the short-term, but also their infection success and development into different stage-specific phenotypes later in their life cycle, through the modification of the parasite's inheritance system. Developmental phenotypic plasticity of S. mansoni is based on epigenetic mechanisms which are also sensitive to environmental cues, but are poorly understood. Here, we argue that specific cues from the environment could lead to changes in parasite development and infectivity, and consequently, environmental signals that come from environmental control measures could be used to influence S. mansoni dynamics and transmission. This approach poses a challenge since epigenetic modification can lead to unexpected and undesired outcomes. However, we suggest that a better understanding of how environmental cues are interpreted by epigenome during schistosome development and host interactions could potentially be applied to control parasite's virulence. We review evidence about the role of environmental cues on the phenotype of S. mansoni and the compatibility between this parasite and its intermediate and definitive hosts.
PY 2019
PD JUN
SO Frontiers In Microbiology
SN 1664-302X
PU Frontiers Media Sa
VL 10
IS 1475
UT 000474746900001
DI 10.3389/fmicb.2019.01475
ID 61941
ER

EF