Natural resistance to Fasciola hepatica (Trematoda) in Pseudosuccinea columella snails: A review from literature and insights from comparative “omic” analyses

Type Article
Date 2019-12
Language English
Author(s) Alba Annia1, 2, Tetreau Guillaume2, Chaparro Cristian2, Sánchez Jorge1, Vázquez Antonio A.1, 3, Gourbal Benjamin2
Affiliation(s) 1 : Centro de Investigaciones, Diagnóstico y Referencia, Instituto de Medicina Tropical “Pedro Kourí”, La Habana, Cuba
2 : University of Perpignan Via Domitia, Interactions Hosts Pathogens Environments UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860, Perpignan, France
3 : MIVEGEC, IRD, CNRS, Université de Montpellier, Montpellier, France
Source Developmental And Comparative Immunology (0145-305X) (Elsevier BV), 2019-12 , Vol. 101 , P. 103463 (14p.)
DOI 10.1016/j.dci.2019.103463
WOS© Times Cited 3
Keyword(s) Transcriptome, Albumen gland, Allocation of resources, Response to stress, Immune defense, Cost of resistance
Abstract

The snail Pseudosuccinea columella is one of the main vectors of the medically-important trematode Fasciola hepatica. In Cuba, the existence of natural P. columella populations that are either susceptible or resistant to F. hepatica infection offers a unique snail-parasite for study of parasite-host compatibility and immune function in gastropods. Here, we review all previous literature on this system and present new “omic” data that provide a molecular baseline of both P. columella phenotypes from naïve snails. Comparison of whole snail transcriptomes (RNAseq) and the proteomes of the albumen gland (2D-electrophoresis, MS) revealed that resistant and susceptible strains differed mainly in an enrichment of particular biological processes/functions and a greater abundance of proteins/transcripts associated with immune defense/stress response in resistant snails. These results indicate a differential allocation of molecular resources to self-maintenance and survival in resistant P. columella that may cause enhanced responsiveness to stressors (i.e. F. hepatica infection or tolerance to variations in environmental pH/total water hardness), possibly as trade-off against reproduction and the ecological cost of resistance previously suggested in resistant populations of P. columella.

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Alba Annia, Tetreau Guillaume, Chaparro Cristian, Sánchez Jorge, Vázquez Antonio A., Gourbal Benjamin (2019). Natural resistance to Fasciola hepatica (Trematoda) in Pseudosuccinea columella snails: A review from literature and insights from comparative “omic” analyses. Developmental And Comparative Immunology, 101, 103463 (14p.). Publisher's official version : https://doi.org/10.1016/j.dci.2019.103463 , Open Access version : https://archimer.ifremer.fr/doc/00509/62039/