FN Archimer Export Format
PT J
TI Natural resistance to Fasciola hepatica (Trematoda) in Pseudosuccinea columella snails: A review from literature and insights from comparative “omic” analyses
BT 
AF Alba, Annia
   Tetreau, Guillaume
   Chaparro, Cristian
   Sánchez, Jorge
   Vázquez, Antonio A.
   Gourbal, Benjamin
AS 1:1,2;2:2;3:2;4:1;5:1,3;6:2;
FF 1:;2:;3:;4:;5:;6:;
C1 Centro de Investigaciones, Diagnóstico y Referencia, Instituto de Medicina Tropical “Pedro Kourí”, La Habana, Cuba
   University of Perpignan Via Domitia, Interactions Hosts Pathogens Environments UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860, Perpignan, France
   MIVEGEC, IRD, CNRS, Université de Montpellier, Montpellier, France
C2 IPK, CUBA
   UNIV PERPIGNAN, FRANCE
   UNIV MONTPELLIER, FRANCE
UM IHPE
IN WOS Cotutelle UMR
   copubli-france
   copubli-int-hors-europe
   copubli-sud
IF 3.192
TC 6
UR https://archimer.ifremer.fr/doc/00509/62039/66180.pdf
LA English
DT Article
DE ;Transcriptome;Albumen gland;Allocation of resources;Response to stress;Immune defense;Cost of resistance
AB The snail Pseudosuccinea columella is one of the main vectors of the medically-important trematode Fasciola hepatica. In Cuba, the existence of natural P. columella populations that are either susceptible or resistant to F. hepatica infection offers a unique snail-parasite for study of parasite-host compatibility and immune function in gastropods. Here, we review all previous literature on this system and present new “omic” data that provide a molecular baseline of both P. columella phenotypes from naïve snails. Comparison of whole snail transcriptomes (RNAseq) and the proteomes of the albumen gland (2D-electrophoresis, MS) revealed that resistant and susceptible strains differed mainly in an enrichment of particular biological processes/functions and a greater abundance of proteins/transcripts associated with immune defense/stress response in resistant snails. These results indicate a differential allocation of molecular resources to self-maintenance and survival in resistant P. columella that may cause enhanced responsiveness to stressors (i.e. F. hepatica infection or tolerance to variations in environmental pH/total water hardness), possibly as trade-off against reproduction and the ecological cost of resistance previously suggested in resistant populations of P. columella. 
PY 2019
PD DEC
SO Developmental And Comparative Immunology
SN 0145-305X
PU Elsevier BV
VL 101
UT 000488141600003
DI 10.1016/j.dci.2019.103463
ID 62039
ER

EF