FN Archimer Export Format
PT J
TI Differences in mitochondrial efficiency explain individual variation in growth performance
BT 
AF SALIN, Karine
   VILLASEVIL, Eugenia M.
   ANDERSON, Graeme J.
   LAMARRE, Simon G.
   MELANSON, Chloe A.
   MCCARTHY, Ian
   SELMAN, Colin
   METCALFE, Neil B.
AS 1:1;2:1;3:1;4:2;5:2;6:3;7:1;8:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;
C1 Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Glasgow G12 8QQ, Lanark, Scotland.
   Univ Moncton, Dept Biol, Moncton, NB E1A 3E9, Canada.
   Bangor Univ, Sch Ocean Sci, Menai Bridge LL59 5AB, Gwynedd, Wales.
C2 UNIV GLASGOW, UK
   UNIV MONCTON, CANADA
   UNIV BANGOR, UK
IF 4.637
TC 39
UR https://archimer.ifremer.fr/doc/00512/62368/66639.pdf
   https://archimer.ifremer.fr/doc/00512/62368/66640.pdf
   https://archimer.ifremer.fr/doc/00512/62368/66641.pdf
LA English
DT Article
DE ;ATP/O ratio;brown trout;energy metabolism;intraspecific;mitochondrial plasticity;protein synthesis
AB The physiological causes of intraspecific differences in fitness components such as growth rate are currently a source of debate. It has been suggested that differences in energy metabolism may drive variation in growth, but it remains unclear whether covariation between growth rates and energy metabolism is: (i) a result of certain individuals acquiring and consequently allocating more resources to growth, and/or is (ii) determined by variation in the efficiency with which those resources are transformed into growth. Studies of individually housed animals under standardized nutritional conditions can help shed light on this debate. Here we quantify individual variation in metabolic efficiency in terms of the amount of adenosine triphosphate (ATP) generated per molecule of oxygen consumed by liver and muscle mitochondria and examine its effects, both on the rate of protein synthesis within these tissues and on the rate of whole-body growth of individually fed juvenile brown trout (Salmo trutta) receiving either a high or low food ration. As expected, fish on the high ration on average gained more in body mass and protein content than those maintained on the low ration. Yet, growth performance varied more than 10-fold among individuals on the same ration, resulting in some fish on low rations growing faster than others on the high ration. This variation in growth for a given ration was related to individual differences in mitochondrial properties: a high whole-body growth performance was associated with high mitochondrial efficiency of ATP production in the liver. Our results show for the first time, to our knowledge, that among-individual variation in the efficiency with which substrates are converted into ATP can help explain marked variation in growth performance, independent of food intake. This study highlights the existence of inter-individual differences in mitochondrial efficiency and its potential importance in explaining intraspecific variation in whole-animal performance. 
PY 2019
PD AUG
SO Proceedings Of The Royal Society B-biological Sciences
SN 0962-8452
PU Royal Soc
VL 286
IS 1909
UT 000482188300009
DI 10.1098/rspb.2019.1466
ID 62368
ER

EF