FN Archimer Export Format
PT J
TI Molecular Targets for Coevolutionary Interactions Between Pacific Oyster Larvae and Their Sympatric Vibrios
BT 
AF Wegner, K. Mathias
   Piel, Damien
   Bruto, Maxime
   John, Uwe
   Mao, Zhijuan
   Alunno-Bruscia, Marianne
   Petton, Bruno
   LE ROUX, Frederique
AS 1:1;2:2,3;3:3;4:4,5;5:6;6:2,7;7:2,7;8:2,3;
FF 1:;2:PDG-RBE-PFOM;3:PDG-RBE-PFOM;4:;5:;6:PDG-RBE-PFOM-LPI;7:PDG-RBE-PFOM-LPI;8:PDG-RBE-PFOM;
C1 Coastal Ecology, Waddensea Station Sylt, Alfred Wegener Institut - Helmholtz-Zentrum für Polar- und Meeresforschung, List, Germany
   Unité Physiologie Fonctionnelle des Organismes Marins, Ifremer, Plouzané, France
   Integrative Biology of Marine Models, UPMC Paris 06, CNRS, UMR 8227, Sorbonne Universités, Station Biologique de Roscoff, Roscoff, France
   Ecolgical Chemistry, Alfred Wegener Institut - Helmholtz-Zentrum für Polar- und Meeresforschung, Bremerhaven, Germany
   Helmholtz Institute for Functional Marine Biodiversity (HIFMB), Oldenburg, Germany
   Biological and Environmental College, Zhejiang Wanli University, Ningbo, China
   LEMAR UMR 6539, Ifremer, Argenton-en-Landunvez, France
C2 INST A WEGENER, GERMANY
   IFREMER, FRANCE
   UNIV PARIS 06, FRANCE
   INST A WEGENER, GERMANY
   UNIV OLDENBURG, GERMANY
   UNIV ZHEJIANG WANLI, CHINA
   IFREMER, FRANCE
SI ROSCOFF
   ARGENTON
SE PDG-RBE-PFOM
   PDG-RBE-PFOM-LPI
UM LEMAR
IN WOS Ifremer UPR
   WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
   copubli-int-hors-europe
   copubli-sud
IF 4.235
TC 6
UR https://archimer.ifremer.fr/doc/00512/62409/66669.pdf
   https://archimer.ifremer.fr/doc/00512/62409/66670.xlsx
   https://archimer.ifremer.fr/doc/00512/62409/66671.xlsx
LA English
DT Article
DE ;virulence;host-pathogen interaction;local adaptation;biological invasion;emerging disease;Wadden Sea
AB Bacteria of the Vibrio genus are the most predominant infectious agents threatening marine wildlife and aquaculture. Due to the large genetic diversity of these pathogens, the molecular determinants of Vibrio virulence are only poorly understood. Furthermore, studies tend to ignore co-evolutionary interactions between different host populations and their locally encountered Vibrio communities. Here, we explore the molecular targets of such co-evolutionary interactions by analyzing the genomes of nine Vibrio strains from the Splendidus-clade showing opposite virulence patterns towards two populations of Pacific oysters introduced into European Wadden Sea. By contrasting Vibrio phylogeny to their host specific virulence patterns, we could identify two core genome genes (OG1907 and OG 3159) that determine the genotype by genotype (G × G) interactions between oyster larvae and their sympatric Vibrio communities. Both genes show positive selection between locations targeting only few amino acid positions. Deletion of each gene led to a loss of the host specific virulence patterns while complementation with OG3159 alleles from both locations could recreate the wild type phenotypes matching the origin of the allele. This indicates that both genes can act as a genetic switch for Vibrio-oyster coevolution demonstrating that local adaptation in distinct Vibrio lineages can rely on only few genes independent of larger pathogenicity islands or plasmids. 
PY 2019
PD SEP
SO Frontiers In Microbiology
SN 1664-302X
PU Frontiers Media SA
VL 10
IS 2067
UT 000484518200001
DI 10.3389/fmicb.2019.02067
ID 62409
ER

EF