TY - JOUR T1 - Deciphering the effect of food availability, growth and host condition on disease susceptibility in a marine invertebrate A1 - Pernet,Fabrice A1 - Tamayo,David A1 - Fuhrmann,Marine A1 - Petton,Bruno AD - Ifremer, UMR LEMAR 6539 (CNRS/UBO/Ifremer/IRD), Technopôle de Brest-Iroise, 29280 Plouzané, France AD - Departamento GAFFA (Animal Physiology), Facultad de Ciencia y Tecnología, Universidad del País Vasco, Apartado 644, 48080 Bilbao, Spain AD - School of Veterinary Science, Faculty of Science, The University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia UR - https://archimer.ifremer.fr/doc/00513/62431/ DO - 10.1242/jeb.210534 KW - Energetics KW - Health KW - Herpesvirus KW - Nutrition KW - Physiological trade-off N2 - Food provisioning influences disease risk and outcome in animal populations in two ways. On the one hand, unrestricted food supply improves the physiological condition of the host and lowers its susceptibility to infectious disease, reflecting a trade-off between immunity and other fitness-related functions. On the other hand, food scarcity limits the resources available to the pathogen and slows the growth and metabolism of the host on which the pathogen depends to proliferate. Here, we investigated how food availability, growth rate and energetic reserves drive the outcome of a viral disease affecting an ecologically relevant model host, the Pacific oyster, Crassostrea gigas. We selected fast- and slow-growing animals, and we exposed them to high and low food rations. We evaluated their energetic reserves, challenged them with a pathogenic virus, monitored daily survival and developed a mortality risk model. Although high food levels and oyster growth were associated with a higher risk of mortality, energy reserves were associated with a lower risk. Food availability acts both as an enabling factor for mortality by increasing oyster growth and as a limiting factor by increasing their energy reserves. This study clarifies how food resources have an impact on susceptibility to disease and indicates how the host's physiological condition could mitigate epidemics. Practically, we suggest that growth should be optimized rather than maximized, considering that trade-offs occur with disease resistance or tolerance. Y1 - 2019/09 PB - The Company of Biologists JF - Journal Of Experimental Biology SN - 0022-0949 VL - 222 IS - 17 ID - 62431 ER -