FN Archimer Export Format
PT J
TI Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana
BT 
AF Falkowski, Michaël
   Jahn-Oyac, Arnaud
   Odonne, Guillaume
   Flora, Claudiane
   Estevez, Yannick
   Touré, Seindé
   Boulogne, Isabelle
   Robinson, Jean-Charles
   Béreau, Didier
   Petit, Philippe
   Azam, Didier
   Coke, Maïra
   Issaly, Jean
   Gaborit, Pascal
   Stien, Didier
   Eparvier, Véronique
   Dusfour, Isabelle
   Houël, Emeline
AS 1:1;2:1;3:2;4:1;5:1;6:1,3;7:1,4,5;8:6;9:6;10:4;11:7;12:7;13:8;14:8;15:9;16:3;17:8,10;18:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:;14:;15:;16:;17:;18:;
C1 CNRS, UMR EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane, 97300 Cayenne, France
   Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens (LEEISA), CNRS, Université de Guyane, IFREMER, 97300 Cayenne, France
   CNRS, Institut de Chimie des Substances Naturelles, UPR2301, Université Paris Saclay, 91198 Gif-sur-Yvette, France
   Université des Antilles, Campus de Fouillole, 97157 Pointe-à-Pitre Cedex, Guadeloupe, France
   Université de ROUEN, UFR des Sciences et Techniques, Laboratoire Glycobiologie et Matrice Extracellulaire Végétale, UPRES-EA 4358, Fédération de Recherche « Normandie Végétal » FED 4277, 76821, Mont-Saint-Aignan, France.
   Université de Guyane, Laboratoire COVAPAM, UMR QualiSud, Campus universitaire de Troubiran, BP 792, 97337 Cayenne cedex, France
   Unité Expérimentale d'Ecologie et d'Ecotoxicologie Aquatique, INRA-U3E, 35042 Rennes, France
   Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Unité Contrôle et Adaptation des vecteurs, 23 avenue Pasteur, BP6010, 97306 Cayenne cedex, France
   Sorbonne Université, CNRS, Laboratoire de Biodiversité et Biotechnologie Microbienne, LBBM, Observatoire Océanologique, 66650 Banyuls-sur-mer, France
   INRS-Institut Armand Frappier, Groupe recherche en écologie microbienne, 531 boulevard des prairies, H7V 1B7, Laval, QC, Canada
C2 CNRS, FRANCE
   CNRS, FRANCE
   CNRS, FRANCE
   UNIV ANTILLES, FRANCE
   UNIV ROUEN, FRANCE
   UNIV GUYANE, FRANCE
   INRA, FRANCE
   INST PASTEUR, FRANCE
   UNIV PARIS 06, FRANCE
   INRS-IAF, CANADA
UM LEEISA
IN WOS Cotutelle UMR
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 0.799
TC 14
UR https://archimer.ifremer.fr/doc/00514/62544/66894.pdf
LA English
DT Article
DE ;Mosquito larvicides;Culicidae;Amazonian chemodiversity;Screening optimization;Quasi-Poisson generalized linear model;Chemical defense
AB Natural products have proven to be an immeasurable source of bioactive compounds. The exceptional biodiversity encountered in Amazonia, alongside a rich entomofauna and frequent interactions with various herbivores is the crucible of a promising chemodiversity. This prompted us to search for novel botanical insecticides in French Guiana. As this French overseas department faces severe issues linked to insects, notably the strong incidence of vector-borne infectious diseases, we decided to focus our research on products able to control the mosquito Aedes aegypti. We tested 452 extracts obtained from 85 species originating from 36 botanical families and collected in contrasted environments against an Aedes aegypti laboratory strain susceptible to all insecticides, and a natural population resistant to both pyrethroid and organophosphate insecticides collected in Cayenne for the most active of them. 8 species (Maytenus oblongata Reissek, Celastraceae; Costus erythrothyrsus Loes., Costaceae; Humiria balsamifera Aubl., Humiriaceae; Sextonia rubra (Mez) van der Werff, Lauraceae; Piper hispidum Sw., Piperaceae; Laetia procera (Poepp.) Eichl., Salicaceae; Matayba arborescens (Aubl.) Radlk., Sapindaceae; and Cupania scrobitulata Rich., Sapindaceae) led to extracts exhibiting more than 50% larval mortality after 48h of exposition at 100 µg/mL against the natural population and were considered active. Selectivity and phytochemistry of these extracts were therefore investigated and discussed, and some active compounds highlighted. Multivariate analysis highlighted that solvents, plant tissues, plant family and location had a significant effect on mortality while light, available resources and vegetation type did not. Through this case study we highlighted that plant defensive chemistry mechanisms are crucial while searching for novel insecticidal products. 
PY 2020
PD JAN
SO Acta Tropica
SN 0001-706X
PU Elsevier BV
VL 201
UT 000500186700003
DI 10.1016/j.actatropica.2019.105179
ID 62544
ER

EF