FN Archimer Export Format
PT J
TI Dosage Compensation throughout the Schistosoma mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome
BT 
AF PICARD, Marion A. L.
   VICOSO, Beatriz
   ROQUIS, David
   BULLA, Ingo
   AUGUSTO, Ronaldo C.
   ARANCIBIA, Nathalie
   GRUNAU, Christoph
   BOISSIER, Jerome
   COSSEAU, Celine
AS 1:2,3;2:2;3:3;4:1;5:1;6:3;7:3;8:3;9:3;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;
C1 Univ Montpellier, Univ Perpignan Via Domitia, IFREMER, IHPE,UMR 5244,CNRS, Perpignan, France.
   IST Austria, Klosterneuburg, Austria.
C2 CNRS, FRANCE
   IST AUSTRIA, AUSTRIA
   UNIV PERPIGNAN, FRANCE
UM IHPE
IN WOS Cotutelle UMR
   DOAJ
   copubli-europe
IF 3.462
TC 8
UR https://archimer.ifremer.fr/doc/00514/62580/66929.pdf
   https://archimer.ifremer.fr/doc/00514/62580/66930.pdf
   https://archimer.ifremer.fr/doc/00514/62580/66931.pdf
   https://archimer.ifremer.fr/doc/00514/62580/66932.pdf
LA English
DT Article
DE ;dosage compensation;chromatin landscape;histone modifications;female heterogamety;Schistosoma mansoni
AB Differentiated sex chromosomes are accompanied by a difference in gene dose between X/Z-specific and autosomal genes. At the transcriptomic level, these sex-linked genes can lead to expression imbalance, or gene dosage can be compensated by epigenetic mechanisms and results into expression level equalization. Schistosoma mansoni has been previously described as a ZW species (i.e., female heterogamety, in opposition to XY male heterogametic species) with a partial dosage compensation, but underlying mechanisms are still unexplored. Here, we combine transcriptomic (RNA-Seq) and epigenetic data (ChIP-Seq against H3K4me3, H3K27me3, and H4K20me1 histone marks) in free larval cercariae and intravertebrate parasitic stages. For the first time, we describe differences in dosage compensation status in ZW females, depending on the parasitic status: free cercariae display global dosage compensation, whereas intravertebrate stages show a partial dosage compensation. We also highlight regional differences of gene expression along the Z chromosome in cercariae, but not in the intravertebrate stages. Finally, we feature a consistent permissive chromatin landscape of the Z chromosome in both sexes and stages. We argue that dosage compensation in schistosomes is characterized by chromatin remodeling mechanisms in the Z-specific region.
PY 2019
PD JUN
SO Genome Biology And Evolution
SN 1759-6653
PU Oxford Univ Press
VL 11
IS 7
UT 000484039500018
BP 1909
EP 1922
DI 10.1093/gbe/evz133
ID 62580
ER

EF