FN Archimer Export Format
PT J
TI Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus
BT 
AF Fassio, Giulia
   Modica, Maria Vittoria
   Mary, Lou
   Zaharias, Paul
   Fedosov, Alexander E.
   Gorson, Juliette
   Kantor, Yuri I.
   Holford, Mandё
   Puillandre, Nicolas
AS 1:1;2:2,3;3:4;4:4;5:5;6:6,7,8;7:5;8:6,7,8;9:4;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;
C1 Department of Biology and Biotechnologies “Charles Darwin”, Sapienza University of Rome, 00185 Rome, Italy
   Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
   University of Montpellier, 34095 Montpellier, France
   Institut Systématique Evolution Biodiversité (ISYEB), Muséum National d’Histoire Naturelle, CNRS, Sorbonne Université, EPHE, Université des Antillles, 57 rue Cuvier, CP 26, 75005 Paris, France
   A.N. Severtzov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninski prospect 33, 119071 Moscow, Russian
   Department of Chemistry, Hunter College, CUNY, New York, NY 10065, USA
   Department of Invertebrate Zoology, The American Museum of Natural History, New York, NY 10024, USA
   Biology, Biochemistry, and Chemistry programs of The CUNY Graduate Center, New York, NY 10016, USA
C2 UNIV ROMA LA SAPIENZA, ITALY
   STAZ ZOOL ANTON DOHRN, ITALY
   UNIV MONTPELLIER, FRANCE
   MNHN, FRANCE
   RUSSIAN ACAD SCI, RUSSIAN
   CUNY, USA
   NHM, USA
   CUNY, USA
IN DOAJ
IF 2.13
TC 15
UR https://archimer.ifremer.fr/doc/00589/70155/68142.pdf
   https://archimer.ifremer.fr/doc/00589/70155/68143.zip
LA English
DT Article
CR KANACONO
BO Alis
DE ;Conidae;conotoxins;turripeptides;transcriptome;venom gland
AB Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining venom evolution and diversity. Venom gland and foot transcriptomes of Profundiconus cf. vaubani and Profundiconus neocaledonicus were de novo assembled, annotated, and analyzed for differential expression. One hundred and thirty-seven venom components were identified from P. cf. vaubani and 82 from P. neocaledonicus, with only four shared by both species. The majority of the transcript diversity was composed of putative peptides, including conotoxins, profunditoxins, turripeptides, insulin, and prohormone-4. However, there were also a significant percentage of other putative venom components such as chymotrypsin and L-rhamnose-binding lectin. The large majority of conotoxins appeared to be from new gene superfamilies, three of which are highly different from previously reported venom peptide toxins. Their low conotoxin diversity and the type of insulin found suggested that these species, for which no ecological information are available, have a worm or molluscan diet associated with a narrow dietary breadth. Our results indicate that Profundiconus venom is highly distinct from that of other cone snails, and therefore important for examining venom evolution in the Conidae family. 
PY 2019
PD NOV
SO Toxins
SN 2072-6651
PU MDPI AG
VL 11
IS 11
UT 000501604700026
DI 10.3390/toxins11110623
ID 70155
ER

EF