FN Archimer Export Format
PT J
TI Identifying adverse outcome pathways (aop) for Amsterdam city fish by integrated field monitoring
BT 
AF van der Oost, Ron
   McKenzie, David
   Verweij, Frank
   Satumalay, Carl
   van der Molen, Natascha
   Winter, Matthew J.
   Chipman, J. Kevin
AS 1:1;2:2;3:1;4:1;5:1;6:3;7:4;
FF 1:;2:;3:;4:;5:;6:;7:;
C1 Technology, Research & Engineering, Waternet Institute for the Urban Water Cycle, Amsterdam, the Netherlands
   UMR Marbec (CNRS–IRD-Ifremer-Université Montpellier), Montpellier, France
   Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon, United Kingdom
   Biosciences, University of Birmingham, B15 2 T T, Birmingham, United Kingdom
C2 WATERNET INST, NETHERLANDS
   CNRS, FRANCE
   UNIV EXETER, UK
   UNIV BIRMINGHAM, UK
UM MARBEC
IN WOS Cotutelle UMR
   copubli-europe
IF 4.86
TC 8
UR https://archimer.ifremer.fr/doc/00592/70451/68775.pdf
LA English
DT Article
DE ;Adverse outcome pathways;Micropollutants risk assessment;Biochemical & physiological biomarkers;Ecological studies
AB The European City Fish project aimed to develop a generic methodology for ecological risk assessment for urban rivers. Since traditional methods only consider a small fraction of substances present in the water cycle, biological effect monitoring is required for a more reliable assessment of the pollution status. A major challenge for environmental risk assessment (ERA) is the application of adverse outcome pathways (AOP), i.e. the linking of pollutant exposure via early molecular and biochemical changes to physiological effects and, ultimately, effects on populations and ecosystems. We investigated the linkage between responses at these different levels. Many AOP aspects were investigated, from external and internal exposure to different classes of micropollutants, via molecular key events (MKE) the impacts on organs and organisms (fish physiology), to changes in the population dynamics of fish. Risk assessment procedures were evaluated by comparing environmental quality standards, bioassay responses, biomarkers in caged and feral fish, and the impact on fish populations. Although no complete AOP was observed, indirect relationships linking pollutant exposure via MKE to impaired locomotion were demonstrated at the most polluted site near a landfill for chemical waste. The pathway indicated that several upstream key events requiring energy for stress responses and toxic defence are likely to converge at a single common MKE: increased metabolic demands. Both fish biomarkers and the bioanalytical SIMONI strategy are valuable indicators for micropollutant risks to fish communities. 
PY 2020
PD FEB
SO Environmental Toxicology And Pharmacology
SN 1382-6689
PU Elsevier BV
VL 74
UT 000514007200016
DI 10.1016/j.etap.2019.103301
ID 70451
ER

EF