FN Archimer Export Format
PT J
TI Ciguatoxin Occurrence in Food-Web Components of a Cuban Coral Reef Ecosystem: Risk-Assessment Implications
BT 
AF Díaz-Asencio, Lisbet
   Clausing, Rachel J.
   Vandersea, Mark
   Chamero-Lago, Donaida
   Gómez-Batista, Miguel
   Hernández-Albernas, Joan I.
   Chomérat, Nicolas
   Rojas-Abrahantes, Gabriel
   Litaker, Wayne
   Tester, Patricia
   Diogène, Jorge
   Alonso-Hernández, Carlos M.
   Dechraoui Bottein, Marie-Yasmine
AS 1:1;2:2,3;3:4;4:1;5:1;6:5;7:6;8:1;9:4;10:7;11:8;12:1,2;13:2,9;
FF 1:;2:;3:;4:;5:;6:;7:PDG-ODE-LITTORAL-LERBO;8:;9:;10:;11:;12:;13:;
C1 Centro de Estudios Ambientales de Cienfuegos, Ciudad Nuclear, Cienfuegos 59350, Cuba
   Environment Laboratories, Department of Nuclear Science and Application, International Atomic Energy Agency, 4 Quai Antoine 1er, MC 98000 Monaco, Monaco
   Department of Ecology and Evolutionary Biology, University of California Los Angeles, 621 Charles E Young Dr S, Los Angeles, CA 90095-1606, USA
   National Oceanic and Atmospheric Administration, National Ocean Service, National Centers for Coastal Ocean Science, Beaufort Laboratory, 101 Pivers Island Rd., Beaufort, NC 28516, USA
   Refugio de Fauna Cayo Santa María, Gaviota S.A., Villa Clara 53100, Cuba
   Ifremer, Laboratory of Environment and Resources Western Britanny, Coastal Research Unit, Place de la Croix, B.P. 40537, 29185 Concarneau CEDEX, France
   Ocean Tester, LLC, 295 Dills Point Road, Beaufort, NC 28516, USA
   Marine Environmental Monitoring, IRTA, Ctra. Poble Nou km 5.5, 43540 Sant Carles de la Ràpita, Spain
   Intergovernmental Oceanographic Commission of UNESCO, IOC Science and Communication Centre on Harmful Algae, University of Copenhagen, 2100 Copenhagen, Denmark
C2 CEAC, CUBA
   IAEA, MONACO
   UNIV CALIF LOS ANGELES, USA
   NOAA, USA
   REFUGIO FAUNA CAYO SANTA MARIA, CUBA
   IFREMER, FRANCE
   OCEAN TESTER LLC, USA
   IRTA, SPAIN
   IOC, DENMARK
SI CONCARNEAU
SE PDG-ODE-LITTORAL-LERBO
IN WOS Ifremer UPR
   DOAJ
   copubli-europe
   copubli-int-hors-europe
   copubli-sud
IF 2.13
TC 28
UR https://archimer.ifremer.fr/doc/00597/70947/69189.pdf
   https://archimer.ifremer.fr/doc/00597/70947/69190.pdf
LA English
DT Article
DE ;Caribbean;ciguatoxicity;qPCR;trophic transfer;ish;food safety;food security;science-based management;foodborne disease
AB In Cuba, ciguatera poisoning associated with fish consumption is the most commonly occurring non-bacterial seafood-borne illness. Risk management through fish market regulation has existed in Cuba for decades and consists of bans on selected species above a certain weight; however, the actual occurrence of ciguatoxins (CTXs) in seafood has never been verified. From this food safety risk management perspective, a study site locally known to be at risk for ciguatera was selected. Analysis of the epiphytic dinoflagellate community identified the microalga Gambierdiscus. Gambierdiscus species included six of the seven species known to be present in Cuba (G. caribaeus, G. belizeanus, G. carpenteri, G. carolinianus, G. silvae, and F. ruetzleri). CTX-like activity in invertebrates, herbivorous and carnivorous fishes were analyzed with a radioligand receptor-binding assay and, for selected samples, with the N2A cell cytotoxicity assay. CTX activity was found in 80% of the organisms sampled, with toxin values ranging from 2 to 8 ng CTX3C equivalents g−1 tissue. Data analysis further confirmed CTXs trophic magnification. This study constitutes the first finding of CTX-like activity in marine organisms in Cuba and in herbivorous fish in the Caribbean. Elucidating the structure–activity relationship and toxicology of CTX from the Caribbean is needed before conclusions may be drawn about risk exposure in Cuba and the wider Caribbean 
PY 2019
PD DEC
SO Toxins
SN 2072-6651
PU MDPI AG
VL 11
IS 12
UT 000507337800045
DI 10.3390/toxins11120722
ID 70947
ER

EF