FN Archimer Export Format
PT J
TI Photochemistry on the Space Station-Antibody Resistance to Space Conditions after Exposure Outside the International Space Station
BT 
AF COUSSOT, Gaelle
   LE POSTOLLEC, Aurelie
   FAYE, Clement
   BAQUE, Mickael
   VANDENABEELE-TRAMBOUZE, Odile
   INCERTI, Sebastien
   VIGIER, Flavie
   CHAPUT, Didier
   COTTIN, Herve
   PRZYBYLA, Bartos
   BERGER, Thomas
   DOBRIJEVIC, Michel
AS 1:1;2:2;3:3;4:4;5:5;6:6;7:;8:7;9:8,9;10:10;11:10;12:2;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;
C1 Univ Montpellier, ENSCM, CNRS, IBMM, F-34093 Montpellier 5, France.
   Univ Bordeaux, CNRS, LAB, Pessac, France.
   Colcom, Cap Alpha, Clapiers, France.
   German Aerosp Ctr DLR, Inst Planetary Res Management & Infrastruct, Res Grp Astrobiol Labs, Berlin, Germany.
   UBO, IUEM UMR 6197, LMEE, Plouzane, France.
   Univ Bordeaux, UMR 5797, CENBG, Gradignan, France.
   Ctr Natl Etud Spatiales, DCT ME EM, Toulouse, France.
   Univ Paris Est Creteil, UMR 7583, LISA, Creteil, France.
   Univ Paris Diderot, Inst Pierre Simon Lapl, Creteil, France.
   German Aerosp Ctr, Inst Aerosp Med, Cologne, Germany.
C2 UNIV MONTPELLIER, FRANCE
   UNIV BORDEAUX, FRANCE
   COLCOM, FRANCE
   GERMAN AEROSP CTR, GERMANY
   UBO, FRANCE
   UNIV BORDEAUX, FRANCE
   CNES, FRANCE
   UNIV UPEC, FRANCE
   UNIV PARIS 07, FRANCE
   GERMAN AEROSP CTR, GERMANY
UM BEEP-LM2E
IN WOS Cotutelle UMR
   copubli-france
   copubli-europe
   copubli-univ-france
IF 4.091
TC 5
UR https://archimer.ifremer.fr/doc/00601/71305/69721.pdf
LA English
DT Article
DE ;Astrobiology;Cosmic rays;Biochip;Antibody;Planetary exploration
AB Antibody-based analytical instruments are under development to detect signatures of life on planetary bodies. Antibodies are molecular recognition reagents able to detect their target at sub-nanomolar concentrations, with high affinity and specificity. Studying antibody binding performances under space conditions is mandatory to convince space agencies of the adequacy of this promising tool for planetary exploration. To complement previous ground-based experiments on antibody resistance to simulated irradiation, we evaluate in this paper the effects of antibody exposure to real space conditions during the EXPOSE-R2 mission outside the International Space Station. The absorbed dose of ionizing radiation recorded during the 588 days of this mission (220 mGy) corresponded to the absorbed dose expected during a mission to Mars. Moreover, samples faced, at the same time as irradiation, thermal cycles, launch constraints, and long-term storage. A model biochip was used in this study with antibodies in freeze-dried form and under two formats: free or covalently grafted to a solid surface. We found that antibody-binding performances were not significantly affected by cosmic radiation, and more than 40% of the exposed antibody, independent of its format, was still functional during all this experiment. We conclude that antibody-based instruments are well suited for in situ analysis on planetary bodies. 
PY 2019
PD AUG
SO Astrobiology
SN 1531-1074
PU Mary Ann Liebert, Inc
VL 19
IS 8
UT 000478581200008
BP 1053
EP 1062
DI 10.1089/ast.2018.1907
ID 71305
ER

EF