FN Archimer Export Format PT J TI Differential basal expression of immune genes confers Crassostrea gigas resistance to Pacific Oyster Mortality Syndrome BT AF DE LORGERIL, Julien PETTON, Bruno LUCASSON, Aude PEREZ, Valérie STENGER, Pierre-Louis DEGREMONT, Lionel MONTAGNANI, Caroline ESCOUBAS, Jean Michel HAFFNER, Philippe ALLIENNE, Jean-François LEROY, Marc LAGARDE, Franck VIDAL DUPIOL, Jeremie GUEGUEN, Yannick MITTA, Guillaume AS 1:1;2:1;3:1;4:1;5:1;6:1;7:1;8:2;9:1;10:2;11:2;12:1;13:1;14:1;15:3; FF 1:PDG-RBE-IHPE;2:PDG-RBE-PFOM-LPI;3:;4:;5:PDG-RBE-RMPF;6:PDG-RBE-SGMM-LGPMM;7:PDG-RBE-IHPE;8:;9:PDG-RBE-IHPE;10:;11:;12:PDG-ODE-LITTORAL-LERLR;13:PDG-RBE-IHPE;14:PDG-RBE-IHPE;15:; C1 Ifremer, france CNRS, france Univ perpignan, France C2 IFREMER, FRANCE CNRS, FRANCE UNIV PERPIGNAN, FRANCE SI MONTPELLIER ARGENTON TAHITI LA TREMBLADE SETE SE PDG-RBE-IHPE PDG-RBE-PFOM-LPI PDG-RBE-RMPF PDG-RBE-SGMM-LGPMM PDG-ODE-LITTORAL-LERLR UM LEMAR MARBEC IHPE EIO IN WOS Ifremer UPR WOS Ifremer UMR WOS Cotutelle UMR DOAJ copubli-france copubli-univ-france IF 3.969 TC 22 UR https://archimer.ifremer.fr/doc/00602/71369/69811.pdf https://archimer.ifremer.fr/doc/00602/71369/69812.pdf https://archimer.ifremer.fr/doc/00602/71369/69813.xlsx https://archimer.ifremer.fr/doc/00602/71369/69814.xlsx https://archimer.ifremer.fr/doc/00602/71369/69815.xlsx https://archimer.ifremer.fr/doc/00602/71369/69816.xlsx https://archimer.ifremer.fr/doc/00602/71369/69817.xlsx LA English DT Article DE ;Pacific oyster;Oyster disease;Resistance;OsHV-1;Antiviral molecular pathways;Invertebrate immunity AB Background: As a major threat to the oyster industry, Pacific Oyster Mortality Syndrome (POMS) is a polymicrobial disease affecting the main oyster species farmed across the world. POMS affects oyster juveniles and became panzootic this last decade, but POMS resistance in some oyster genotypes has emerged. While we know some genetic loci associated with resistance, the underlying mechanisms remained uncharacterized. So, we developed a comparative transcriptomic approach using basal gene expression profiles between different oyster biparental families with contrasted phenotypes when confronted to POMS (resistant or susceptible). Results: We showed that POMS resistant oysters show differential expression of genes involved in stress responses, protein modifications, maintenance of DNA integrity and repair, and immune and antiviral pathways. We found similarities and clear differences among different molecular pathways in the different resistant families. These results suggest that the resistance process is polygenic and partially varies according to the oyster genotype. Conclusions: We found differences in basal expression levels of genes related to TLR-NFκB, JAK-STAT and STING-RLR pathways. These differences could explain the best antiviral response, as well as the robustness of resistant oysters when confronted to POMS. As some of these genes represent valuable candidates for selective breeding, we propose future studies should further examine their function. PY 2020 PD JAN SO Bmc Genomics SN 1471-2164 PU Research Square VL 21 IS 1 UT 000513858100006 DI 10.1186/s12864-020-6471-x ID 71369 ER EF