FN Archimer Export Format
PT J
TI Sporochartines A-E, A New Family of Natural Products from the Marine Fungus Hypoxylon monticulosum Isolated from a Sphaerocladina Sponge
BT 
AF LEMAN-LOUBIERE, Charlotte
   LE GOFF, Geraldine
   DEBITUS, Cecile
   OUAZZANI, Jamal
AS 1:1;2:1;3:2;4:1;
FF 1:;2:;3:;4:;
C1 Centre National de la Recherche Scientifique, Institut de Chimie des Substances Naturelles ICSN, Gif-sur-Yvette, France
   LEMAR, IRD, Centre National de la Recherche Scientifique, IFREMER, Université de Bretagne Occidentale, IUEM, Technopole Brest-Iroise, Plouzané, France
C2 CNRS, FRANCE
   IRD, FRANCE
UM LEMAR
IN DOAJ
IF 5.247
TC 14
UR https://archimer.ifremer.fr/doc/00602/71415/69899.pdf
   https://archimer.ifremer.fr/doc/00602/71415/69900.pdf
LA English
DT Article
DE ;Hypoxylon;Sphaerocladina;sporothriolide;sporochartines;cytotoxic compounds
AB Four new sporochartines B-E were isolated from the marine fungus Hypoxylon monticulosurn CLL-205, isolated from a sponge belonging to the Sphaerocladina order and collected in Tahiti coast. Sporochartine A (1), the first representative of this family was previously isolated from the same fungus. The structures of sporochartines B-E were elucidated using 1D and 2D NMR, HRMS and IR data. Their configurations were established according to ROE correlations and comparison with the absolute configuration of sporochartine A (1) previously obtained from X-ray analysis. Sporochartines A-D (2-4) may be derived from endo Diels-Alderase type catalysis and sporochartine E (5) from an exo Diels-Alderase catalysis. The spatial conformation of sporochartines drastically influences the results of the cytotoxic bioassay against HCT-116, PC-3, and MCF-7 human cancer cell lines. 
PY 2017
SO Frontiers In Marine Science
SN 2296-7745
VL 4
IS 399
UT 000457690600396
DI 10.3389/fmars.2017.00399
ID 71415
ER

EF