FN Archimer Export Format
PT J
TI Acute Oral Toxicity of Pinnatoxin G in Mice
BT 
AF SOSA, Silvio
   PELIN, Marco
   CAVION, Federica
   HERVE, Fabienne
   HESS, Philipp
   TUBARO, Aurelia
AS 1:1;2:1;3:1;4:2;5:2;6:1;
FF 1:;2:;3:;4:PDG-ODE-DYNECO-PHYC;5:PDG-ODE-DYNECO-PHYC;6:;
C1 Department of Life Sciences, University of Trieste, Via A. Valerio 6, 34127 Trieste, Italy
   Ifremer, Laboratoire Phycotoxines, Centre Atlantique, 44311 Nantes Cedex, France
C2 UNIV TRIESTE, ITALY
   IFREMER, FRANCE
SI NANTES
SE PDG-ODE-DYNECO-PHYC
IN WOS Ifremer UPR
   DOAJ
   copubli-europe
IF 2.13
TC 17
UR https://archimer.ifremer.fr/doc/00605/71724/70190.pdf
LA English
DT Article
DE ;Vulcanodinium rugosum;pinnatoxin G;dinoflagellates;harmful algae;oral toxicity
AB Pinnatoxin G (PnTx-G) is a marine cyclic imine toxin produced by the dinoflagellate Vulcanodinium rugosum, frequently detected in edible shellfish from Ingril Lagoon (France). As other pinnatoxins, to date, no human poisonings ascribed to consumption of PnTx-G contaminated seafood have been reported, despite its potent antagonism at nicotinic acetylcholine receptors and its high and fast-acting toxicity after intraperitoneal or oral administration in mice. The hazard characterization of PnTx-G by oral exposure is limited to a single acute toxicity study recording lethality and clinical signs in non-fasted mice treated by gavage or through voluntary food ingestion, which showed differences in PnTx-G toxic potency. Thus, an acute toxicity study was carried out using 3 h-fasted CD-1 female mice, administered by gavage with PnTx-G (8–450 µg kg−1). At the dose of 220 µg kg−1 and above, the toxin induced a rapid onset of clinical signs (piloerection, prostration, hypothermia, abdominal breathing, paralysis of the hind limbs, and cyanosis), leading to the death of mice within 30 min. Except for moderate mucosal degeneration in the small intestine recorded at doses of 300 µg kg−1, the toxin did not induce significant morphological changes in the other main organs and tissues, or alterations in blood chemistry parameters. This acute oral toxicity study allowed to calculate an oral LD50 for PnTx-G equal to 208 g kg−1 (95% confidence limits: 155–281 µg kg−1) and to estimate a provisional NOEL of 120 µg kg−1. 
PY 2020
PD FEB
SO Toxins
SN 2072-6651
PU MDPI AG
VL 12
IS 2
UT 000519117300051
DI 10.3390/toxins12020087
ID 71724
ER

EF