About frame estimation of growth functions and robust prediction in bioprocess modeling

Type Article
Date 2020-01
Language English
Author(s) Krichen Emna1, 2, Rapaport A.3, Fouilland Eric2
Affiliation(s) 1 : Univ Montpellier, INRA, SupAgro, MISTEA, Montpellier, France.
2 : Univ Montpellier, IFREMER, CNRS, IRD,MARBEC, Montpellier, France.
3 : Univ Montpellier, INRA, SupAgro, MISTEA, Montpellier, France.
Source Journal Of Process Control (0959-1524) (Elsevier Sci Ltd), 2020-01 , Vol. 85 , P. 121-135
DOI 10.1016/j.jprocont.2019.11.009
Keyword(s) Functional estimation, Interval observers, Growth functions, Least square

We address the problem of determining functional framing from experimental data points in view of robust time-varying predictions, which is of crucial importance in bioprocess monitoring. We propose a method that provides guaranteed functional bounds, instead of sets of parameters values for growth functions such as the classical Monod or Haldane functions commonly used in bioprocess modeling. We illustrate the applicability of the method with bioreactor simulations in batch and continuous mode, as well as on real data. We also present two extensions of the method adding flexibility in its application, and discuss its efficiency in providing guaranteed state estimations.

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