FN Archimer Export Format PT J TI About frame estimation of growth functions and robust prediction in bioprocess modeling BT AF KRICHEN, Emna RAPAPORT, A. FOUILLAND, Eric AS 1:1,2;2:3;3:2; FF 1:;2:;3:; C1 Univ Montpellier, INRA, SupAgro, MISTEA, Montpellier, France. Univ Montpellier, IFREMER, CNRS, IRD,MARBEC, Montpellier, France. Univ Montpellier, INRA, SupAgro, MISTEA, Montpellier, France. C2 MONTPELLIER SUPAGRO, FRANCE CNRS, FRANCE INRA, FRANCE UM MARBEC IN WOS Cotutelle UMR copubli-france IF 3.666 TC 0 UR https://archimer.ifremer.fr/doc/00609/72149/73205.pdf LA English DT Article DE ;Functional estimation;Interval observers;Growth functions;Least square AB We address the problem of determining functional framing from experimental data points in view of robust time-varying predictions, which is of crucial importance in bioprocess monitoring. We propose a method that provides guaranteed functional bounds, instead of sets of parameters values for growth functions such as the classical Monod or Haldane functions commonly used in bioprocess modeling. We illustrate the applicability of the method with bioreactor simulations in batch and continuous mode, as well as on real data. We also present two extensions of the method adding flexibility in its application, and discuss its efficiency in providing guaranteed state estimations. PY 2020 PD JAN SO Journal Of Process Control SN 0959-1524 PU Elsevier Sci Ltd VL 85 UT 000510953100011 BP 121 EP 135 DI 10.1016/j.jprocont.2019.11.009 ID 72149 ER EF