Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia

Type Article
Date 2020-02
Language English
Author(s) Aimond Axelle1, 2, Calabro Kevin3, Audoin Coralie2, Olivier Elodie1, Dutot Mélody1, Buron Pauline1, Rat Patrice1, Laprévote Olivier1, Prado Soizic4, Roulland Emmanuel4, Thomas Olivier P.3, Genta-Jouve Grégory1, 5
Affiliation(s) 1 : Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
2 : Laboratoires Clarins, 5 Rue Ampère, 95300 Pontoise, France
3 : Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland
4 : Muséum National d’Histoire Naturelle, Unité Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245, CP 54, 57 rue Cuvier, 75005 Paris, France
5 : Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens (LEEISA), USR 3456, Université De Guyane, CNRS Guyane, 275 Route de Montabo, 97334 Cayenne, French Guiana
Source Molecules (1420-3049) (MDPI AG), 2020-02 , Vol. 25 , N. 3 , P. 589 (10p.)
DOI 10.3390/molecules25030589
WOS© Times Cited 5
Note This article belongs to the Special Issue Terpenes and Terpene Derivatives
Keyword(s) Sideritis hyssopifolia, ent-kaurane, anti-inflammatory, NMR

This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity.

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Aimond Axelle, Calabro Kevin, Audoin Coralie, Olivier Elodie, Dutot Mélody, Buron Pauline, Rat Patrice, Laprévote Olivier, Prado Soizic, Roulland Emmanuel, Thomas Olivier P., Genta-Jouve Grégory (2020). Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia. Molecules, 25(3), 589 (10p.). Publisher's official version : , Open Access version :