FN Archimer Export Format PT J TI Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia BT AF Aimond, Axelle Calabro, Kevin Audoin, Coralie Olivier, Elodie Dutot, Mélody Buron, Pauline Rat, Patrice Laprévote, Olivier Prado, Soizic Roulland, Emmanuel Thomas, Olivier P. Genta-Jouve, Grégory AS 1:1,2;2:3;3:2;4:1;5:1;6:1;7:1;8:1;9:4;10:4;11:3;12:1,5; FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:; C1 Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France Laboratoires Clarins, 5 Rue Ampère, 95300 Pontoise, France Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland Muséum National d’Histoire Naturelle, Unité Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245, CP 54, 57 rue Cuvier, 75005 Paris, France Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens (LEEISA), USR 3456, Université De Guyane, CNRS Guyane, 275 Route de Montabo, 97334 Cayenne, French Guiana C2 UNIV PARIS 04, FRANCE LAB CLARINS, FRANCE UNIV NATL IRELAND, IRELAND MNHN, FRANCE CNRS, FRANCE UM LEEISA IN WOS Cotutelle UMR DOAJ copubli-france copubli-europe IF 0.182 TC 5 UR https://archimer.ifremer.fr/doc/00610/72214/71012.pdf https://archimer.ifremer.fr/doc/00610/72214/71013.pdf LA English DT Article DE ;Sideritis hyssopifolia;ent-kaurane;anti-inflammatory;NMR AB This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity. PY 2020 PD FEB SO Molecules SN 1420-3049 PU MDPI AG VL 25 IS 3 UT 000515384800159 DI 10.3390/molecules25030589 ID 72214 ER EF