FN Archimer Export Format
PT J
TI A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas
BT 
AF Lafont, Maxime
   Vergnes, Agnes
   Vidal-Dupiol, Jeremie
   de Lorgeril, Julien
   Gueguen, Yannick
   Haffner, Philippe
   Petton, Bruno
   Chaparro, Cristian
   Barrachina, Celia
   Destoumieux-Garzon, Delphine
   Mitta, Guillaume
   Gourbal, Benjamin
   Montagnani, Caroline
AS 1:1,2;2:1;3:1;4:1;5:1;6:1;7:3;8:2;9:5;10:1;11:2;12:2;13:1;
FF 1:;2:PDG-RBE-IHPE;3:PDG-RBE-IHPE;4:PDG-RBE-IHPE;5:PDG-RBE-IHPE;6:PDG-RBE-IHPE;7:PDG-RBE-PFOM-LPI;8:;9:;10:;11:;12:;13:PDG-RBE-IHPE;
C1 IHPE, University of Montpellier, CNRS, Ifremer, University of Perpignan Via Domitia, Montpellier, France
   IHPE, University of Montpellier, CNRS, Ifremer, University of Perpignan Via Domitia, Perpignan, France
   Ifremer, LEMAR UMR6539, Argenton-en-Landunvez, France
   MGX, Biocampus Montpellier, CNRS, INSERM, University of Montpellier, Montpellier, France
   IHPE, University of Montpellier, CNRS, Ifremer, University of Perpignan Via Domitia, Montpellier, France
C2 IFREMER, FRANCE
   UNIV PERPIGNAN, FRANCE
   IFREMER, FRANCE
   CNRS, FRANCE
   CNRS, FRANCE
SI MONTPELLIER
   ARGENTON
SE PDG-RBE-IHPE
   PDG-RBE-PFOM-LPI
UM LEMAR
   IHPE
IN WOS Ifremer UMR
   WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 7.867
TC 48
UR https://archimer.ifremer.fr/doc/00614/72580/71541.pdf
   https://archimer.ifremer.fr/doc/00614/72580/71542.xlsx
   https://archimer.ifremer.fr/doc/00614/72580/71543.tif
   https://archimer.ifremer.fr/doc/00614/72580/71544.tif
   https://archimer.ifremer.fr/doc/00614/72580/71545.xlsx
   https://archimer.ifremer.fr/doc/00614/72580/71546.xlsx
   https://archimer.ifremer.fr/doc/00614/72580/71547.eps
   https://archimer.ifremer.fr/doc/00614/72580/71548.xlsx
   https://archimer.ifremer.fr/doc/00614/72580/71549.xlsx
   https://archimer.ifremer.fr/doc/00614/72580/71550.tif
   https://archimer.ifremer.fr/doc/00614/72580/71551.tif
LA English
DT Article
DE ;innate immunity;priming;OsHV-1;antiviral response;immune memory;oyster;POMS;poly(I-C);interferon;transcriptomic
AB Over the last decade, innate immune priming has been evidenced in many invertebrate phyla. If mechanistic models have been proposed, molecular studies aiming to substantiate these models have remained scarce. We reveal here the transcriptional signature associated with immune priming in the oyster Crassostrea gigas. Oysters were fully protected against Ostreid herpesvirus 1 (OsHV-1), a major oyster pathogen, after priming with poly(I·C), which mimics viral double-stranded RNA. Global analysis through RNA sequencing of oyster and viral genes after immune priming and viral infection revealed that poly(I·C) induces a strong antiviral response that impairs OsHV-1 replication. Protection is based on a sustained upregulation of immune genes, notably genes involved in the interferon pathway and apoptosis, which control subsequent viral infection. This persistent antiviral alert state remains active over 4 months and supports antiviral protection in the long term. This acquired resistance mechanism reinforces the molecular foundations of the sustained response model of immune priming. It further opens the way to applications (pseudovaccination) to cope with a recurrent disease that causes dramatic economic losses in the shellfish farming industry worldwide. 
PY 2020
PD MAR
SO Mbio
SN 2150-7511
PU American Society for Microbiology
VL 11
IS 2
UT 000531071300058
DI 10.1128/mBio.02777-19
ID 72580
ER

EF