FN Archimer Export Format
PT J
TI Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites
BT 
AF TENNESSEN, Jacob A.
   THERON, Andre
   MARINE, Melanie
   YEH, Jan-Ying
   ROGNON, Anne
   BLOUIN, Michael S.
AS 1:1;2:2;3:1;4:1;5:2;6:1;
FF 1:;2:;3:;4:;5:;6:;
C1 Oregon State Univ, Dept Integrat Biol, Corvallis, OR 97331 USA.
   Univ Perpignan, CNRS, UMR 5244, Ecol & Evolut Interact 2EI, F-66025 Perpignan, France.
C2 UNIV OREGON STATE, USA
   UNIV PERPIGNAN, FRANCE
UM IHPE
IN DOAJ
IF 6.661
TC 50
UR https://archimer.ifremer.fr/doc/00615/72714/71716.pdf
   https://archimer.ifremer.fr/doc/00615/72714/71717.pdf
   https://archimer.ifremer.fr/doc/00615/72714/71718.pdf
   https://archimer.ifremer.fr/doc/00615/72714/71719.xls
LA English
DT Article
AB Schistosomiasis, a neglected global pandemic, may be curtailed by blocking transmission of the parasite via its intermediate hosts, aquatic snails. Elucidating the genetic basis of snail-schistosome interaction is a key to this strategy. Here we map a natural parasite-resistance polymorphism from a Caribbean population of the snail Biomphalaria glabrata. In independent experimental evolution lines, RAD genotyping shows that the same genomic region responds to selection for resistance to the parasite Schistosoma mansoni. A dominant allele in this region conveys an 8-fold decrease in the odds of infection. Fine-mapping and RNA-Seq characterization reveal a <1Mb region, the Guadeloupe Resistance Complex (GRC), with 15 coding genes. Seven genes are single-pass transmembrane proteins with putative immunological roles, most of which show strikingly high nonsynonymous divergence (5-10%) among alleles. High linkage disequilibrium among three intermediate-frequency (>25%) haplotypes across the GRC, a significantly non-neutral pattern, suggests that balancing selection maintains diversity at the GRC. Thus, the GRC resembles immune gene complexes seen in other taxa and is likely involved in parasite recognition. The GRC is a potential target for controlling transmission of schistosomiasis, including via genetic manipulation of snails. 
PY 2015
PD MAR
SO Plos Genetics
SN 1553-7404
PU Public Library Science
VL 11
IS 3
UT 000352197100049
DI 10.1371/journal.pgen.1005067
ID 72714
ER

EF