FN Archimer Export Format
PT J
TI Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids
BT 
AF MOODIE, Lindon W. K.
   CERVIN, Gunnar
   TREPOS, Rozenn
   LABRIERE, Christophe
   HELLIO, Claire
   PAVIA, Henrik
   SVENSON, Johan
AS 1:1,2;2:3;3:4;4:1;5:4;6:3;7:1,5;
FF 1:;2:;3:;4:;5:;6:;7:;
C1 UiT Arctic Univ Norway, Dept Chem, N-9037 Tromso, Norway.
   Umea Univ, Dept Chem, SE-90187 Umea, Sweden.
   Univ Gothenburg, Dept Marine Sci Tjarno, SE-45296 Stromstad, Sweden.
   Univ Bretagne Occidentale, Biodimar LEMAR UMR 6539, Rue Dumont dUrville, F-29280 Plouzane, France.
   RISE Res Inst Sweden, Dept Chem Mat & Surfaces, Box 857, SE-50115 Boras, Sweden.
C2 UNIV TROMSO, NORWAY
   UNIV UMEA, SWEDEN
   UNIV GOTHENBURG, SWEDEN
   UBO, FRANCE
   RISE, SWEDEN
UM LEMAR
IF 2.798
TC 16
UR https://archimer.ifremer.fr/doc/00616/72793/72102.pdf
   https://archimer.ifremer.fr/doc/00616/72793/72103.pdf
LA English
DT Article
DE ;Antifouling;Dihydrostilbene;Batatasin;Oxime;Ianthelline;Hybrid
AB By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 mu g/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low mu g/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prepared compounds are highly active as antifoulants, no apparent synergy is observed by incorporating the oxime functionality into the dihydrostilbene scaffold. This observation is discussed in light of recently reported literature data on related marine natural antifoulants and antifouling hybrids as a potentially general strategy for generation of improved antifoulants. 
PY 2018
PD APR
SO Marine Biotechnology
SN 1436-2228
PU Springer
VL 20
IS 2
UT 000429402200012
BP 257
EP 267
DI 10.1007/s10126-018-9802-z
ID 72793
ER

EF