FN Archimer Export Format PT J TI Sponge-Inspired Dibromohemibastadin Prevents and Disrupts Bacterial Biofilms without Toxicity BT AF LE NORCY, Tiffany NIEMANN, Hendrik PROKSCH, Peter TAIT, Karen LINOSSIER, Isabelle REHEL, Karine HELLIO, Claire FAY, Fabienne AS 1:1;2:2;3:2;4:3;5:1;6:1;7:4;8:1; FF 1:;2:;3:;4:;5:;6:;7:;8:; C1 Univ Bretagne Sud, Inst Univ Europeen Mer, Lab Biotechnol & Chim Marines, F-56100 Lorient, France. Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany. Plymouth Marine Lab, Plymouth PL1 3DH, Devon, England. Univ Bretagne Occidentale, Inst Europeen Mer, LEMAR UMR 6539, Biodimar, F-29200 Brest, France. C2 UBS, FRANCE UNIV DUSSELDORF, GERMANY PML, UK UBO, FRANCE UM LEMAR IN DOAJ IF 4.379 TC 6 UR https://archimer.ifremer.fr/doc/00616/72813/72581.pdf LA English DT Article DE ;biofouling;biofilm;bastadin derivative;microfouling;quorum sensing;sponge AB Since the banning of several families of compounds in antifouling (AF) coatings, the search for environmentally friendly AF compounds has intensified. Natural sources of AF compounds have been identified in marine organisms and can be used to create analogues in laboratory. In a previous study, we identified that dibromohemibastadin-1 (DBHB) is a promising AF molecule, leading to the inhibition of the activity of phenoloxidase, an enzyme involved in the attachment of mussels to surfaces. This paper describes the activity of the DBHB on biofilm formation and its detachment and on bacterial adhesion and communication: quorum sensing. DBHB has an anti-biofilm activity without affecting adhesion of marine and terrestrial bacteria at a dose of 10 mu M. Moreover, DBHB activity on quorum sensing (QS) is demonstrated at doses of 8 and 16 mu M. The activity of DBHB on QS is compared to kojic acid, a quorum sensing inhibitor already described. This compound is a promising environmentally friendly molecule potentially useful for the inhibition of microfouling. PY 2017 PD JUN SO Marine Drugs SN 1660-3397 PU Mdpi Ag VL 15 IS 7 UT 000406685900030 DI 10.3390/md15070222 ID 72813 ER EF