FN Archimer Export Format
PT J
TI Vibrio splendidus   O-antigen structure: A trade-off between virulence to oysters and resistance to grazers
BT 
AF Oyanedel, Daniel
   Labreuche, Yannick
   Bruto, Maxime
   Amraoui, Hajar
   Robino, Etienne
   Haffner, Philippe
   Rubio, Tristan
   Charrière, Guillaume
   LE ROUX, Frederique
   Destoumieux-Garzón, Delphine
AS 1:1,5;2:2,3;3:2,3;4:5;5:1,5;6:1;7:4,5;8:5;9:2,3;10:5;
FF 1:;2:PDG-RBE-PFOM;3:PDG-RBE-PFOM;4:;5:;6:PDG-RBE-IHPE;7:;8:;9:PDG-RBE-PFOM;10:;
C1 IHPE, Univ Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia; Montpellier, France
   Ifremer, Unité Physiologie Fonctionnelle des Organismes Marins, ZI de la Pointe du Diable, CS 10070; F-29280 Plouzané, France
   Sorbonne Universités, UPMC Paris 06, CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074; F-29688, Roscoff cedex, France
   Univ Lyon, CNRS, UMR 5086, Mol Microbiol & Struct Biochem, F-69367 Lyon, France
   IHPE, Univ Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia; Montpellier, France
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV SORBONNE, FRANCE
   UNIV LYON, FRANCE
   UNIV MONTPELLIER, FRANCE
SI MONTPELLIER
   ROSCOFF
SE PDG-RBE-IHPE
   PDG-RBE-PFOM
UM IHPE
IN WOS Ifremer UPR
   WOS Ifremer UMR
   WOS Cotutelle UMR
   copubli-france
   copubli-univ-france
IF 5.491
TC 12
UR https://archimer.ifremer.fr/doc/00619/73070/72194.pdf
LA English
DT Article
AB A major debate in evolutionary biology is whether virulence is maintained as an adaptive trait and/or evolves to non‐virulence. In the environment, virulence traits of non‐obligatory parasites are subjected to diverse selective pressures and trade‐offs. Here we focus on a population of Vibrio splendidus that displays moderate virulence for oysters. A MARTX (Multifunctional‐autoprocessing repeats‐in‐toxin) and a type‐six secretion system (T6SS) were found to be necessary for virulence toward oysters, while a region (wbe) involved in O‐antigen synthesis is necessary for resistance to predation against amoebae. Gene inactivation within the wbe region had major consequences on the O‐antigen structure, conferring lower immunogenicity, competitive advantage and increased virulence in oyster experimental infections. Therefore, O‐antigen structures that favor resistance to environmental predators result in an increased activation of the oyster immune system and a reduced virulence in that host. These trade‐offs likely contribute to maintaining O‐antigen diversity in the marine environment by favoring genomic plasticity of the wbe region. The results of this study indicate an evolution of V. splendidus toward moderate virulence as a compromise between fitness in the oyster as a host, and resistance to its predators in the environment. 
PY 2020
PD OCT
SO Environmental Microbiology
SN 1462-2912
PU Wiley
VL 22
IS 10
UT 000523212500001
BP 4264
EP 4278
DI 10.1111/1462-2920.14996
ID 73070
ER

EF