TY - JOUR T1 - Within-Generation Polygenic Selection Shapes Fitness-Related Traits across Environments in Juvenile Sea Bream A1 - Rey,Carine A1 - Darnaude,Audrey A1 - Ferraton,Franck A1 - Guinand,Bruno A1 - Bonhomme,François A1 - Bierne,Nicolas A1 - Gagnaire,Pierre-Alexandre AD - ISEM, Univ Montpellier, CNRS, EPHE, IRD, Montpellier, France AD - Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratoire de Biologie et Modélisation de la Cellule, 15 parvis Descartes, F-69007 Lyon, France AD - MARBEC, Univ Montpellier, CNRS, IRD, Ifremer, 34095 Montpellier, France UR - https://archimer.ifremer.fr/doc/00622/73370/ DO - 10.3390/genes11040398 KW - antagonistic pleiotropy KW - habitat association KW - fitness trade-off KW - juvenile growth KW - polygenic scores KW - RAD-sequencing KW - spatially varying selection N2 - Understanding the genetic underpinnings of fitness trade-o s across spatially variable environments remains a major challenge in evolutionary biology. In Mediterranean gilthead sea bream, first-year juveniles use various marine and brackish lagoon nursery habitats characterized by a trade-o between food availability and environmental disturbance. Phenotypic di erences among juveniles foraging in di erent habitats rapidly appear after larval settlement, but the relative role of local selection and plasticity in phenotypic variation remains unclear. Here, we combine phenotypic and genetic data to address this question. We first report correlations of opposite signs between growth and condition depending on juvenile habitat type. Then, we use single nucleotide polymorphism (SNP) data obtained by Restriction Associated DNA (RAD) sequencing to search for allele frequency changes caused by a single generation of spatially varying selection between habitats. We found evidence for moderate selection operating at multiple loci showing subtle allele frequency shifts between groups of marine and brackish juveniles. We identified subsets of candidate outlier SNPs that, in interaction with habitat type, additively explain up to 3.8% of the variance in juvenile growth and 8.7% in juvenile condition; these SNPs also explained significant fraction of growth rate in an independent larval sample. Our results indicate that selective mortality across environments during early-life stages involves complex trade-o s between alternative growth strategies Y1 - 2020/04 PB - MDPI AG JF - Genes SN - 2073-4425 VL - 11 IS - 4 ID - 73370 ER -