FN Archimer Export Format PT J TI Sensing Polymer/Paracetamol Interaction with an Independent Component Analysis-Based SERS-MIP Nanosensor BT AF Decorbie, N. Tijunelyte, I. Gam-Derouich, S. Solard, J. Lamouri, A. Decorse, P. Felidj, N. Gauchotte-Lindsay, C. Rinnert, Emmanuel Mangeney, C. Lidgi-Guigui, N. AS 1:1;2:1;3:2;4:3;5:2;6:2;7:2;8:4;9:5;10:2,6;11:1; FF 1:;2:;3:;4:;5:;6:;7:;8:;9:PDG-REM-GM-LCG;10:;11:; C1 CSPBAT, (now LSPM), Sorbonne Paris Nord, 99 Av. JB Clément, 93430, Villetaneuse, France Univ Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR CNRS 71086, 75013, Paris, France Centrale de Proximité en Nanotechnologies de Paris Nord, Sorbonne Paris Nord, 99, Av. JB Clément, 93430, Villetaneuse, France James Watt School of Engineering, University of Glasgow, Rankine Building, Oakfield Avenue, G12 8LT, Glasgow, UK IFREMER, RDT-LDCM, Technopole Brest-Iroise, 29280, Plouzané, France University of Paris, Lab Chim & Biochim Pharmacolog & Toxicol, UMR 8601, 75006, Paris, France C2 CSPBAT, FRANCE UNIV PARIS 07, FRANCE UNIV PARIS 13, FRANCE UNIV GLASGOW, UK IFREMER, FRANCE UNIV PARIS, FRANCE SI BREST SE PDG-REM-GM-LCG IN WOS Ifremer UPR copubli-france copubli-europe copubli-univ-france IF 2.404 TC 11 UR https://archimer.ifremer.fr/doc/00628/73962/73386.pdf LA English DT Article DE ;Sensor;SERS;Molecularly imprinted polymers;Emerging pollutant;Paracetamol;Independent component analysis AB In this article, we propose a new strategy to build a sensor for easy handling and rapid analysis on-site. Our sensor is based on the combination of surface-enhanced Raman spectroscopy (SERS) and molecularly imprinted polymers (MIPs). SERS provides a strong sensitivity for the detection of trace molecules while MIPs offer a highly selective and specific recognition platform. The research presented here focuses on the detection of the interaction between a robust ultra-thin layer of MIPs and of paracetamol, the targeted molecule. This drug is an environmental emerging pollutant, i.e., a molecule whose presence and significance have not yet been elucidated, which gives rise to health and environmental concerns. The results are a combined analysis of the SERS spectra and a multivariate analysis. The former provides a clear demonstration of the evolution of the MIP-nanostructure interaction when the concentration of paracetamol increases. The statistical analysis produces the proof of the selectivity of the sensor PY 2020 PD OCT SO Plasmonics SN 1557-1955 PU Springer Science and Business Media LLC VL 15 IS 5 UT 000529856000001 BP 1533 EP 1539 DI 10.1007/s11468-020-01177-9 ID 73962 ER EF