FN Archimer Export Format PT J TI Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp. BT AF Tintillier, Florent Moriou, Céline Petek, Sylvain Fauchon, Marilyne Hellio, Claire SAULNIER, Denis Ekins, Merrick Hooper, John N. A. Al-Mourabit, Ali Debitus, Cecile AS 1:1;2:2;3:1,3;4:3;5:3;6:4;7:5;8:5;9:2;10:1,3; FF 1:PDG-RBE-RMPF;2:;3:;4:;5:;6:PDG-RBE-RMPF;7:;8:;9:;10:; C1 IRD, Université de la Polynésie française, Ifremer, ILM, EIO, Papeete F-98713, French Polynesia Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, 91190 Gif-sur-Yvette, France IRD, Univ Brest, CNRS, Ifremer, LEMAR, F-29280 Plouzane, France Ifremer, IRD, ILM, Université de la Polynésie française, EIO, Taravao F-98719, French Polynesia Queensland Museum, PO Box 3300, South Brisbane BC, Queensland 4101, Australia C2 IRD, FRANCE CNRS, FRANCE IRD, FRANCE IFREMER, FRANCE QUEENSLAND MUSEUM, AUSTRALIA SI TAHITI SE PDG-RBE-RMPF UM LEMAR EIO IN WOS Ifremer UMR WOS Cotutelle UMR DOAJ copubli-france copubli-p187 copubli-int-hors-europe IF 1.103 TC 15 UR https://archimer.ifremer.fr/doc/00630/74200/73825.pdf https://archimer.ifremer.fr/doc/00630/74200/73826.pdf LA English DT Article DE ;sponge;Pseudoceratina;quorum sensing inhibitory activity;antifouling;Verongiida;bromotyrosine AB Four new brominated tyrosine metabolites, aplyzanzines C–F (1–4), were isolated from the French Polynesian sponge Pseudoceratina n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A (5) and 6, previously isolated, respectively, from the sponges Psammaplysilla purpurea and Verongula sp. Their structures were assigned based on the interpretation of their NMR and HRMS data. The compounds exhibited quorum sensing inhibition (QSi) and antifouling activities against several strains of bacteria and microalgae. To our knowledge, the QSi activity of this type of bromotyrosine metabolite is described here for the first time. PY 2020 PD MAY SO Marine Drugs SN 1660-3397 PU MDPI AG VL 18 IS 5 UT 000541031900020 DI 10.3390/md18050272 ID 74200 ER EF