FN Archimer Export Format PT J TI Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil BT AF Mosnier, Emilie Dusfour, Isabelle Lacour, Guillaume Saldanha, Raphael Guidez, Amandine Gomes, Margarete S. Sanna, Alice Epelboin, Yanouk Restrepo, Johana Davy, Damien Demar, Magalie Djossou, Félix Douine, Maylis Ardillon, Vanessa Nacher, Mathieu Musset, Lise Roux, Emmanuel AS 1:1,2;2:3;3:3,4;4:5;5:3;6:6;7:7;8:3;9:8;10:9;11:10,11;12:1;13:11,12;14:13;15:12;16:14;17:15,16; FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:;14:;15:;16:;17:; C1 Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier Andrée Rosemon, rue des flamboyants, 97306, Cayenne, French Guiana Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, Marseille, France Unité Contrôle et Adaptation des Vecteurs, Institut Pasteur de la Guyane, 23 avenue Pasteur, 97306, Cayenne, French Guiana Altopictus, 67 avenue Maréchal Juin, 64200, Biarritz, France LIS, ICICT, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, Brazil; International Join Laboratory Sentinela, IRD, Fiocruz, University of Brasília, Rio de Janeiro, Brazil Superintendência de Vigilância em Saúde do Amapá (SVS-AP), Av. 13 de Setembro, 1889 – Buritizal, Macapá, Amapá, Brazil Agence Régionale de la Santé, 66 rue des flamboyants, 97306, Cayenne, French Guiana Service d’Entomologie de la Direction Démoustication et Actions Sanitaires, collectivité Térritoriale de Guyane, carrefour de suzini 4179 route de montabo, 97307, Cayenne, French Guiana LEEISA (Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens), CNRS, Université de Guyane, IFREMER, 275 route de Montabo, 97300, Cayenne, France Laboratoire de Parasitologie et Mycologie, Centre Hospitalier Andrée Rosemon, rue des flamboyants, 97306, Cayenne, French Guiana Université de Guyane, EA3593 Ecosystèmes Amazoniens et Pathologie Tropicale, Cayenne, French Guiana Centre d’Investigation Clinique Antilles Guyane – Inserm 1424, Centre Hospitalier Andrée Rosemon, rue des flamboyants, 97306, Cayenne, French Guiana CIRE Guyane, 66 rue des flamboyants, 97306, Cayenne, French Guiana Laboratoire de parasitologie, Centre National de Référence du Paludisme, Pôle Zones Endémiques, WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, Institut Pasteur de la Guyane, 23 avenue Pasteur, 97306, Cayenne, French Guiana ESPACE-DEV, IRD, Universités de Montpellier, de La Réunion, de la Guyane, des Antilles, Montpellier, France: LIS, ICICT, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, Brazil International Join Laboratory Sentinela, IRD, Fiocruz, University of Brasília, Rio de Janeiro, Brazil C2 CENT HOSP CAYENNE, FRANCE UNIV AIX MARSEILLE, FRANCE INST PASTEUR, FRANCE ALTOPICTUS, FRANCE UNIV BRASILIA, BRAZIL SVS-AP, BRAZIL ARS GUYANE, FRANCE COLLECTIV TERRIT GUYANE, FRANCE CNRS, FRANCE CENT HOSP CAYENNE, FRANCE UNIV GUYANE, FRANCE INSERM, FRANCE CIRE GUYANE, FRANCE INST PASTEUR, FRANCE IRD, BRAZIL UNIV BRASILIA, BRAZIL UM LEEISA IN WOS Cotutelle UMR DOAJ copubli-france copubli-univ-france copubli-int-hors-europe copubli-sud IF 0.958 TC 16 UR https://archimer.ifremer.fr/doc/00632/74387/74081.pdf https://archimer.ifremer.fr/doc/00632/74387/74082.pdf https://archimer.ifremer.fr/doc/00632/74387/74083.pdf https://archimer.ifremer.fr/doc/00632/74387/86963.pdf LA English DT Article DE ;Plasmodium vivax;Anopheles darlingi;French Guiana;Brazil;Transnational;Outbreak investigation;Indigenous south Americans;Malaria;Amazonia AB Background In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017. Methods Two investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Number and location of malaria cases were estimated using French and Brazilian surveillance systems. Results On the French Guianese side of the border in Saint-Georges de l’Oyapock, the attack rate was 5.5% (n = 4000), reaching 51.4% (n = 175) in one Indigenous neighborhood. Entomological findings suggest a peak of Anopheles darlingi density in August and September. Two female An. darlingi (n = 1104, 0.18%) were found to be Pv-positive during this peak. During the same period, aggregated data from passive surveillance conducted by Brazilian and French Guianese border health centers identified 1566 cases of Pv infection. Temporal distribution during the 2007–2018 period displayed seasonal patterns with a peak in November 2017. Four clusters were identified among epidemic profiles of cross-border area localities. All localities of the first two clusters were Brazilian. The localization of the first cluster suggests an onset of the outbreak in an Indigenous reservation, subsequently expanding to French Indigenous neighborhoods and non-Native communities. Conclusions The current findings demonstrate a potential increase in malaria cases in an area with otherwise declining numbers. This is a transborder region where human mobility and remote populations challenge malaria control programs. This investigation illustrates the importance of international border surveillance and collaboration for malaria control, particularly in Indigenous villages and mobile populations. PY 2020 PD MAY SO Bmc Infectious Diseases SN 1471-2334 PU Springer Science and Business Media LLC VL 20 IS 1 UT 000537854900001 DI 10.1186/s12879-020-05086-4 ID 74387 ER EF