FN Archimer Export Format
PT J
TI Microplastics induce dose-specific transcriptomic disruptions in energy metabolism and immunity of the pearl oyster Pinctada margaritifera
BT 
AF Gardon, Tony
   Morvan, Lucie
   Huvet, Arnaud
   Quillien, Virgile
   Soyez, Claude
   Le Moullac, Gilles
   Le Luyer, Jeremy
AS 1:1;2:1;3:2;4:1,2;5:1;6:1;7:1;
FF 1:PDG-RBE-RMPF;2:;3:PDG-RBE-PFOM-LPI;4:PDG-RBE-PFOM-LPI;5:PDG-RBE-RMPF;6:PDG-RBE-RMPF;7:PDG-RBE-RMPF;
C1 Ifremer, Institut Louis‐Malardé, IRD, Univ Polynésie Française, EIO, F-98719, Taravao, Tahiti, Polynésie française, France
   Univ Brest, Ifremer, CNRS, IRD, LEMAR, F-29280, Plouzané, France
C2 IFREMER, FRANCE
   IFREMER, FRANCE
SI TAHITI
   BREST
SE PDG-RBE-RMPF
   PDG-RBE-PFOM-LPI
UM LEMAR
   EIO
IN WOS Ifremer UMR
IF 8.071
TC 38
UR https://archimer.ifremer.fr/doc/00640/75213/75351.pdf
   https://archimer.ifremer.fr/doc/00640/75213/75352.docx
LA English
DT Article
DE ;Microbeads;Marine bivalve;Differentially expressed genes;Stress response;Energy-limited tolerance
AB A combined approach integrating bioenergetics and major biological activities is essential to properly understand the impact of microplastics (MP) on marine organisms. Following experimental exposure of polystyrene microbeads (micro-PS of 6 and 10 μm) at 0.25, 2.5, and 25 μg L−1, which demonstrated a dose-dependent decrease of energy balance in the pearl oyster Pinctada margaritifera, a transcriptomic study was conducted on mantle tissue. Transcriptomic data helped us to decipher the molecular mechanisms involved in P. margaritifera responses to micro-PS and search more broadly for effects on energetically expensive maintenance functions. Genes related to the detoxification process were impacted by long-term micro-PS exposure through a decrease in antioxidant response functioning, most likely leading to oxidative stress and damage, especially at higher micro-PS doses. The immune response was also found to be dose-specific, with a stress-related activity stimulated by the lowest dose present after a 2-month exposure period. This stress response was not observed following exposure to higher doses, reflecting an energy-limited capacity of pearl oysters to cope with prolonged stress and a dramatic shift to adjust to pessimum conditions, mostly limited and hampered by a lowered energetic budget. This preliminary experiment lays the foundation for exploring pathways and gene expression in P. margaritifera, and marine mollusks in general, under MP exposure. We also propose a conceptual framework to properly assess realistic MP effects on organisms and population resilience in future investigations. 
PY 2020
PD NOV
SO Environmental Pollution
SN 0269-7491
PU Elsevier BV
VL 266
IS Part 3
UT 000571443200012
DI 10.1016/j.envpol.2020.115180
ID 75213
ER

EF