FN Archimer Export Format
PT J
TI An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring
BT 
AF Blanc, Mélanie
   Alfonso, Sebastien
   Bégout, Marie-Laure
   Barrachina, Célia
   Hyötyläinen, Tuulia
   Keiter, Steffen H.
   Cousin, Xavier
AS 1:1;2:2,3;3:2;4:4;5:1;6:1;7:5,6;
FF 1:;2:PDG-RBE-MARBEC-LAAAS;3:PDG-RBE-MARBEC-LAAAS;4:;5:;6:;7:;
C1 Man-Technology-Environment Research Centre (MTM), School of Science and Technology, Örebro University, Fakultetsgatan 1, S-701 82 Örebro, Sweden
   MARBEC, Univ. Montpellier, CNRS, Ifremer, IRD, Route de Maguelone, F-34250 Palavas-les-Flots, France
   COISPA Tecnologia & Ricerca, Stazione Sperimentale per lo Studio delle Risorse del Mare, Via dei Trulli, n 18, 70126 Bari, Italy
   MGX, Univ. Montpellier, CNRS, INSERM, Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France
   Université Paris-Saclay, AgroParisTech, INRAE, GABI, Domaine de Vilvert, F-78350 Jouy-en-Josas, France
   MARBEC, Univ. Montpellier, CNRS, Ifremer, IRD, Route de Maguelone, F-34250 Palavas-les-Flots, France
C2 UNIV OREBRO, SWEDEN
   IFREMER, FRANCE
   COISPA TECNOLOGIA & RICERCA, ITALY
   UNIV MONTPELLIER, FRANCE
   INRAE, FRANCE
   INRAE, FRANCE
SI PALAVAS
SE PDG-RBE-MARBEC-LAAAS
UM MARBEC
IN WOS Ifremer UMR
   WOS Cotutelle UMR
   copubli-france
   copubli-p187
   copubli-europe
   copubli-univ-france
IF 10.754
TC 19
UR https://archimer.ifremer.fr/doc/00646/75797/76720.pdf
   https://archimer.ifremer.fr/doc/00646/75797/76875.docx
   https://archimer.ifremer.fr/doc/00646/75797/76876.xlsx
LA English
DT Article
DE ;Danio rerio;Persistent-organic pollutant;Neurotoxicity;Brain metabolism;RNA-Seq
AB Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants still present in aquatic environments despite their total or partial ban. Previously, we observed that an environmentally realistic mixture of these compounds affects energy balance, growth, and reproduction in exposed zebrafish (F0), and behavior in their unexposed offspring (F1-F4). In the present work, we performed lipidomic and transcriptomic analyses on brains of zebrafish (F0-F2) from exposed and control lineages to identify molecular changes that could explain the observed phenotypes. The use of both technologies highlighted that F0 zebrafish displayed impaired mitochondrial function and lipid metabolism regulation (depletion in triacylglycerols and phospholipids) which can explain disruption of energy homeostasis. A subset of the regulated biological pathways related to energetic metabolism and neurotransmission were inherited in F2. In addition, there were increasing effects on epigenetic pathways from the F0 to the F2 generation. Altogether, we show that the effects of an environmental exposure to PCBs and PBDEs on energetic metabolism as well as neurotransmission extend over 2 generations of zebrafish, possibly due to transgenerational epigenetic inheritance. 
PY 2021
PD FEB
SO Science Of The Total Environment
SN 0048-9697
PU Elsevier BV
VL 754
UT 000593899600029
DI 10.1016/j.scitotenv.2020.142097
ID 75797
ER

EF