FN Archimer Export Format
PT J
TI Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells
BT 
AF Hughes, Kristelle
   Ho, Raimana
   Greff, Stéphane
   Filaire, Edith
   Ranouille, Edwige
   Chazaud, Claire
   Herbette, Gaëtan
   Butaud, Jean-François
   Berthon, Jean-Yves
   Raharivelomanana, Phila
AS 1:1;2:1;3:2;4:3,4;5:3;6:5;7:6;8:7;9:3;10:1;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;
C1 IFREMER, ILM, IRD, EIO UMR 241, Université Polynésie Française, BP 6570, F-98702 Faaa, Tahiti, French Polynesia
   Institut Méditerranéen de Biodiversité et d’Ecologie Marine et Continentale (IMBE), UMR 7263 CNRS, IRD, Aix Marseille Université, Avignon Université, Station Marine d’Endoume, rue de la Batterie des Lions, 13007 Marseille, France
   Greentech SA, Biopôle Clermont-Limagne, 63360 Saint-Beauzire, France
   UMR 1019 INRA-UcA, UNH (Human Nutrition Unity), ECREIN Team, Université Clermont Auvergne, 63000 Clermont-Ferrand, France
   GReD Institute, Université Clermont Auvergne, CNRS, Inserm, Faculté de Médecine, CRBC, 63000 Clermont-Ferrand, France
   Aix Marseille Univ, CNRS, Centrale Marseille, FSCM, Spectropole, Service 511, Campus Saint-Jérome, 13397 Marseille CEDEX 20, France
   Consultant in Forestry and Polynesian Botany, BP 52832, 98716 Pirae, Tahiti, French Polynesia
C2 UNIV POLYNESIE FRANCAISE, FRANCE
   UNIV AIX MARSEILLE, FRANCE
   GREENTECH SA, FRANCE
   INRA, FRANCE
   UNIV CLERMONT AUVERGNE, FRANCE
   UNIV AIX MARSEILLE, FRANCE
   Consultant in Forestry and Polynesian Botany, BP 52832, 98716 Pirae, Tahiti, French Polynesia
UM EIO
IN WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 0.182
TC 5
UR https://archimer.ifremer.fr/doc/00652/76409/77453.pdf
   https://archimer.ifremer.fr/doc/00652/76409/77454.zip
LA English
DT Article
DE ;Polynesian plants;ethnobotany;cosmetopoeia;dermal papilla;hair growth;Wnt
AB Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth 
PY 2020
PD OCT
SO Molecules
SN 1420-3049
PU MDPI AG
VL 25
IS 19
UT 000587163100001
DI 10.3390/molecules25194360
ID 76409
ER

EF