The first head-tailed virus, MFTV1, infecting hyperthermophilic methanogenic deep-sea archaea

Type Article
Date 2021-07
Language English
Author(s) Thiroux Sarah1, Dupont Samuel1, Nesbø Camilla L.2, 3, Bienvenu Nadège1, Krupovic Mart4, L'Haridon Stephane1, Marie Dominique5, Forterre Patrick4, 6, Godfroy AnneORCID7, Geslin Claire1
Affiliation(s) 1 : Univ Brest, CNRS, IFREMER, Laboratoire de Microbiologie des Environnements Extrêmes F‐29280 Plouzané, France
2 : Biozone University of Toronto Toronto Ontario M5S 3E5 ,Canada
3 : Department of Biological Sciences University of Alberta Edmonton AB T6G2R3, 12 ,Canada
4 : Institut Pasteur, Unité de Biologie Moléculaire du Gène chez les Extrêmophiles, Département de Microbiologie 75015 Paris, France
5 : Sorbonne University, UPMC Univ Paris 06, INSU‐CNRS, UMR 7144, Station Biologique de Roscoff 29680 Roscoff, France
6 : Université Paris‐Saclay, Institut de biologie intégrative de la cellule, Laboratoire de Biologie Moléculaire du Gène chez les Extremophiles (LBMGE), UMR8621/CNRS 91405 Orsay Cedex, France
Source Environmental Microbiology (1462-2912) (Wiley), 2021-07 , Vol. 23 , N. 7 , P. 3614-3626
DOI 10.1111/1462-2920.15271
WOS© Times Cited 2
Note Special Issue on Ecophysiology of Extremophiles

Deep‐sea hydrothermal vents are inhabited by complex communities of microbes and their viruses. Despite the importance of viruses in controlling the diversity, adaptation and evolution of their microbial hosts, to date, only eight bacterial and two archaeal viruses isolated from abyssal ecosystems have been described. Thus, our efforts focused on gaining new insights into viruses associated with deep‐sea autotrophic archaea. Here, we provide the first evidence of an infection of a hyperthermophilic methanogenic archaea by a head‐tailed virus, Methanocaldococcus fervens tailed virus 1 (MFTV1). MFTV1 has an isometric head of 50 nm in diameter and a 150 nm‐long non‐contractile tail. Virions are released continuously without causing a sudden drop in host growth. MFTV1 infects Methanocaldococcus species and is the first hyperthermophilic head‐tailed virus described thus far. The viral genome is a double‐stranded linear DNA of 31 kb. Interestingly, our results suggest potential strategies adopted by the plasmid pMEFER01, carried by M. fervens, to spread horizontally in hyperthermophilic methanogens. The data presented here opens a new window of understanding on how the abyssal mobilome interacts with hyperthermophilic marine archaea.

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Thiroux Sarah, Dupont Samuel, Nesbø Camilla L., Bienvenu Nadège, Krupovic Mart, L'Haridon Stephane, Marie Dominique, Forterre Patrick, Godfroy Anne, Geslin Claire (2021). The first head-tailed virus, MFTV1, infecting hyperthermophilic methanogenic deep-sea archaea. Environmental Microbiology, 23(7), 3614-3626. Publisher's official version : , Open Access version :