FN Archimer Export Format
PT J
TI High temperature induces transcriptomic changes in   Crassostrea gigas   that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival
BT 
AF Delisle, Lizenn
   Pauletto, Marianna
   Vidal-Dupiol, Jeremie
   Petton, Bruno
   Bargelloni, Luca
   Montagnani, Caroline
   Pernet, Fabrice
   Corporeau, Charlotte
   Fleury, Elodie
AS 1:1,2;2:3;3:4;4:1;5:3;6:4;7:1;8:1;9:1;
FF 1:PDG-RBE-PFOM-LPI;2:;3:PDG-RBE-IHPE;4:PDG-RBE-PFOM-LPI;5:;6:PDG-RBE-IHPE;7:PDG-RBE-PFOM-LPI;8:PDG-RBE-PFOM-LPI;9:PDG-RBE-PFOM-LPI;
C1 Ifremer, Université de Brest, CNRS, IRD, LEMAR, F-29280 Plouzané, France
   Cawthron Institute, 98 Halifax Street East, Private Bag 2, Nelson 7042, New Zealand
   Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Legnaro, Padova, Italy
   IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan, Via Domitia, F-34095 Montpellier, France
C2 IFREMER, FRANCE
   INST CAWTHRON, NEW ZEALAND
   UNIV PADOVA, ITALY
   IFREMER, FRANCE
SI BREST
   MONTPELLIER
   ARGENTON
SE PDG-RBE-PFOM-LPI
   PDG-RBE-IHPE
UM LEMAR
   IHPE
IN WOS Ifremer UMR
   copubli-europe
   copubli-int-hors-europe
IF 3.312
TC 20
UR https://archimer.ifremer.fr/doc/00656/76806/77974.pdf
LA English
DT Article
DE ;Anti-viral molecular pathway;Host-pathogen interaction;Marine disease;OsHV-1;Resistance;Temperature
AB Of all environmental factors, seawater temperature plays a decisive role in triggering marine diseases. Like fever in vertebrates, high seawater temperature could modulate the host response to pathogens in ectothermic animals. In France, massive mortality of Pacific oysters, Crassostrea gigas, caused by the ostreid herpesvirus 1 (OsHV-1) is markedly reduced when temperatures exceed 24°C in the field. In the present study we assess how high temperature influences the host response to the pathogen by comparing transcriptomes (RNA sequencing) during the course of experimental infection at 21°C (reference) and 29°C. We show that high temperature induced host physiological processes that are unfavorable to the viral infection. Temperature influenced the expression of transcripts related to the immune process and increased the transcription of genes related to the apoptotic process, synaptic signaling and protein processes at 29°C. Concomitantly, the expression of genes associated with catabolism, metabolite transport, macromolecule synthesis and cell growth remained low from the first stage of infection at 29°C. Moreover, viral entry into the host might have been limited at 29°C by changes in extracellular matrix composition and protein abundance. Overall, these results provide new insights into how environmental factors modulate host–pathogen interactions. 
PY 2020
PD OCT
SO Journal Of Experimental Biology
SN 0022-0949
PU The Company of Biologists
VL 223
IS 20
UT 000589086900009
DI 10.1242/jeb.226233
ID 76806
ER

EF